STUDIES ON IN VIVO AND IN VITRO EFFECTS OF PRE-EXPOSURE TO LINDANE ON COUMAPHOS TOXICITY IN RATS AND ISOLATED RABBIT ILEUM
STUDIES ON IN VIVO AND IN VITRO EFFECTS OF PRE-EXPOSURE TO LINDANE ON COUMAPHOS TOXICITY IN RATS AND ISOLATED RABBIT ILEUM
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Date
1993-01
Authors
RAMON-YUSUF, SULEIMAN BABATUNDE (DVM).
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Abstract
Investigations were conducted into the in vitro and in vivo
effects of pre-exposure to lindane on coumaphos toxicity.
In vitro Lindane was found to attenuate the response of the
cholinergic receptor to coumaphos. When the calcium ion
concentration of the medium was reduced by use of the calcium
antagonist nifedipine, an augmentation of the effect of Lindane
was observed.
This effect became more profound as indicated by weaker
muscular contractions in a calcium - free medium.
A 10-week subchronic toxicity study in rats suggests that
pre-exposure to Lindane offers some protection against coumaphos
toxicity as indicated by the mildness of the histopathological
lesions in groups of animals pretreated with Lindane vis-a-vis
those that did not receive lindane pretreatment prior to
exposure to the same dose levels of coumaphos.
The intraperitoneal median lethal dose (LD50) of coumaphos
in rats was found to be 139.6 mg/kg.
In Lindane pre-teated and non pre-treated animals, coumaphos
did not affect the organ; body weight ratio.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA.
IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD
OF THE DECREE OF MASTER OF SCIENCE IN ENVIRONMENTAL TOXICOLOGY
DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY
FACULTY OF VETERINARY MEDICINE
AHMADU BELLO UNIVERSITY,
ZARIA, NIGERIA.
JANUARY, 1993
Keywords
VIVO,, VITRO EFFECTS,, PRE-EXPOSURE, LINDANE,, COUMAPHOS,, TOXICITY,, RATS,, ISOLATED,, RABBIT ILEUM