SPECTROSCOPIC STUDIES AND KINETICS OF CYCLISATION OF N-CARBOBEZOXY-L--AMINO ACIDS WITH ETHANOIC-ANHYDRIDE

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dc.contributor.authorLADAN, ZAKARI
dc.date.accessioned2014-02-11T09:16:20Z
dc.date.available2014-02-11T09:16:20Z
dc.date.issued1999-03
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILMENT OF THE REQUIRMENTS FOR THE DEGREE OF MASTER OF SCIENCE (ORGANIC CHEMISTRY)en_US
dc.description.abstractThe spectroscopic and kinetics of cyclisation of Ncarbobenzoxy- L-a-amino acid derivatives to form their oxazol-5(4H)-ones were studied. The absorption maxima of the amino acid derivatives were found to be affected by the polarities of various solvents employed. Polar solvents shifted the max to longer wavelengths. The shifts have been attributed to either n —> or transitions respectively. The cyclisation rates of N-carbobenzoxy-L-a-amino acids studied were found to be influenced by the nature and size of the alkyl groups at the a-carbon as well as the substituent group at the nitrogen atom. The rate constants were affected by the size of the alkyl groups. The rate constants obtained from the linear plots of time versus logarithm of absorbances of each of the amino acids were used to correlate the linear free energy relationships using the Taft-equations. The steric and polar factor contributions were found to greatly influence the cyclisation rates.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1033
dc.language.isoenen_US
dc.subjectSPECTROSCOPICen_US
dc.subjectSTUDIESen_US
dc.subjectKINETICSen_US
dc.subjectCYCLISATIONen_US
dc.subjectN-CARBOBEZOXYen_US
dc.subjectL--AMINOen_US
dc.subjectACIDSen_US
dc.subjectETHANOICen_US
dc.subjectANHYDRIDEen_US
dc.titleSPECTROSCOPIC STUDIES AND KINETICS OF CYCLISATION OF N-CARBOBEZOXY-L--AMINO ACIDS WITH ETHANOIC-ANHYDRIDEen_US
dc.typeThesisen_US
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