Computation and modeling of the flux of gamma globulin molecules onto titanium surface
Computation and modeling of the flux of gamma globulin molecules onto titanium surface
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Date
2012-02
Authors
Ekwumemgbo, P. A.
Kagbu, J. A.
Nok, A. J.
Omoniyi, K. I.
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Abstract
Titanium (Ti) is widely employed for various biomedical applications due to its biocompatibility.
Studies of γ-globulin adsorption onto Ti are important for the development of biocompatible
devices. This work examines the rate of adsorption of γ-globulin onto Ti surface. The plot of γ-
globulin adsorption onto Ti versus time shows that the initial γ-globulin adsorption increased
linearly with time with the rate constant obtained 0.032min-1 while the correlation coefficient (R2)
is 0.9999. The experimental adsorption rate is limited by the availability of γ-globulin molecules at
the adsorbing surface, resulting in a situation in which, most γ-globulin molecule that collides with
the surface sticks to it. In order to predict the factors that determine the rate of adsorption, the
flux of γ-globulin molecules onto Ti surface was computed by developing a model similar to
implantation of Ti into the body for the transport-limited of γ-globulin adsorption onto Ti from
flowing γ-globulin solution. It was deduced that the rate of this adsorption is determined by the
wall shear rate, the diffusivity of γ-globulin and the bulk amount of γ-globulin solution. An
adsorption model was developed in order to seek the factors that determine the intrinsic
(qualitative) adsorption and desorption rate constants. The experimental adsorption data was
likened to a simple γ-globulin adsorption model, which comprises of adsorption and desorption
processes. The model incorporated the rate of diffusion through the boundary (unstirred) layer of
constant thickness by solving for the Fick's law. It was deduced that the intrinsic adsorption and
desorption rate constants of γ- globulin onto Ti surface.
Description
postprint journal article
Keywords
Computation,, modeling,, flux of gamma,, globulin molecules,, titanium surface,