IMMUNOLOGICAL RESPONSES IN SEXUALLY TRANSMITTED DISEASES
IMMUNOLOGICAL RESPONSES IN SEXUALLY TRANSMITTED DISEASES
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Date
1997-09
Authors
ENI, ROLAND NDUKWE
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Abstract
The lymphocyte sub-populations cd3, CD4, CDS, CDI9 were determined in the blood of fifty
patients each with acute uncomplicated Neisseria gonorrhoea: Chlamydia trachomatis and
Haemophilus ducreyi genital infection. Macrophage migration inhibition factor (MIF) test to
purified protein derivative (PPD) to assess functional cell mediated immunity and the polymorph
function test for the evaluation of phagocytosis and bactericidal activity were also assessed in
the same patients. Comparison was made of the above results with thirty (30) normal healthy
age. and sex matched controls.
Neisseria gonorrhoea studies
The mean lymphocyte subsets CD3, CD8, CD19 absolute numbers were raised compared to
control subjects, although not significantly (p > 0.05) in all the patients. CD4 cells percentages
in thirteen patients (26%) were below the value in the normal healthy control, although not
significantly (p=0.01). There is tendency to reversal of the CD4/CD8 cell ratio in this disease.
The study suggests that T-cell were activated during this disease, and that they may have a role
in the containment of this infection. Macrophage inhibition factor test, indicated that there is
a partial acquired cell mediated immunity in gonococcal urethritis and cervicitis.
The polymorph function using Staphylococcus aureus as assay test indicated that there is no
impairment in the polymorphonuclear leucocyte cell function in comparison to controls.
Chlamydia trachomatis studies.
The study in Chlamydia trachomatis genital infection showed that there is no significant increase
in lymphocyte subsets of CD3, CD8, CD19, p > 0.05. Fourteen (14) or 28% of the patients
had CD4 cells below the mean of the control subjects, though none significantly, p > 0.05. The
CD4/CD8 cell ratio was not inverted in this disease.
Acquired protective cell mediated immunity in Chlamydia trachomatis genital infection was
assessed by the Macrophage Migration Inhibition Factor (MIF), a cytokine. The study showed
that there is complete acquired protective cell mediated immunity in chlamydia genital infection,
though p < 0.05.
The Bacterial Killing Index (BKI) was assayed by the ability of the neutrophil to ingest
Staphylococcus aureus. There was no impairment in the polymorphous cells to eliminate
Staphylococcus aureus of capacity. Therefore, there is no impairment of polymorph function in
Chlamydia genital infection.
Haemophilus ducreyi studies.
The study in Haemophilus ducreyi genital infection indicated that nine (9) or. 18% of the
patients' CD3 cells were below the control value: Fourteen (14) or 28% of the patients' CD8
cells were below the control value Eleven (11I) or 22% of the patients' CD8 cells below the
control value, all these differences were not significant p > 0.05. The CD1.9 cells of all the
patients were above, the normal control subjects, though not significant, p > 0.05.
The cell mediated immunity was assessed by measurement of the Macrophage Migration
Inhibition Factor (MIF), a lymphocyte. The study indicated that there is a incomplete cell
mediated acquired immunity in H. ducreyi genital ulcer. The poly-morph function was assessed
and found to be intact.
Description
A thesis submitted to the Postgraduate School,
Ahmadu Bello University, Zaria.
In partial fulfillment of the requirements for
the award of the degree of
Master of Science (IMMUNOLOGY) MEDICINE
IMMUNOLOGY UNIT
Dept of Medicine
Faculty of Medicine
Ahinadu Bello University
Zaria.
SEPT. 1997
Keywords
IMMUNOLOGICAL,, RESPONSES,, SEXUALLY,, TRANSMITTED,, DISEASES