A COMPARATIVE STUDY OF THE EFFECTS OF GONADECTOMY AND TAMOXIFEN TREATMENT ON ACID GASTRIC SECRETION IN ALBINO RATS

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Date
1995-03
Authors
ETTARH, REMAKE RENNER
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Abstract
The effects of gonadectomy and tamoxifen administration on basal and histamine-stimulated gastric acid secretion in male and females rats were studied. The effects on body and stomach weights were also studied. Gonadectomy was performed 30 days prior to gastric acid secretion estimation, and tamoxifen was administered subcutaneously for 30 days before gastric acid secretion estimation. Gastric acid output was determined by the continuous perfusion methoi of Ghosh and Schild (1958). Both basal and histamine-stimu1ated gastric acid secretion in 14 castrated male rats were not significantly difference from those in 14 tamoxifen-treated nale rats (P > 0.001). Similarly, there was no significant difference between basal and histaminestimulated gastric acid secretion in 14 ovariectomized rats, and 14 tamoxifen-treated female rats (p > 0.001). Basal and histamine-Stimulated gastric Acid outputs were significantly reduced in tamoxifen-treated male rats ( P < 0.001), bolow the values obtained from 12 control male rats. This effect increased as the duration of treatment was increased. In female rats, basal and histamine-stimulated gastric acid secretion both Increased following tamoxifen administration, above the value for 12 control female rat3 (P < 0.001). This response also increased with increase in the duration of tamoxifen administration. Castrated male rat3 and tamoxifen-treated male rats both gained significantly less weight than control male rats (P<0.001). Ovariectomized rats gained significantly more weight than control female rats (P < 0.001). Tamoxifen-treated female rats gained no weight throughout the period of treatment. Stomach weights were not significantly different (P > 0.001) in either gonadectomized or tamoxifen-trsated male and female rats. The effect of tamoxifen on gastric acid secretion in male rats is likely due to its antiandrogenic effect, while the result observed in female rats may be due to its antagonism of oestrogen. The results suggest that the susceptibility of males and females to peptic ulceration is not greater following tamoxifen administration than it is after castration or ovariectomy.
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A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL AHMADU BELLO UNIVERSITY, ZARIA In partial fulfillment of the requirements for the degree of MASTER OF SCIENCE DEPARTMENT OF HUMAN PHYSIOLOGY FACULTY OF MEDICINE AHMADU BELLO UNIVERSITY ZARIA, NIGERIA MARCH, 1995
Keywords
COMPARATIVE,, EFFECTS,, GONADECTOMY,, TAMOXIFEN,, TREATMENT,, ACID,, GASTRIC,, SECRETION,, ALBINO,, RATS.
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