A COMPARATIVE STUDY OF THE EFFECTS OF GONADECTOMY AND TAMOXIFEN TREATMENT ON ACID GASTRIC SECRETION IN ALBINO RATS
A COMPARATIVE STUDY OF THE EFFECTS OF GONADECTOMY AND TAMOXIFEN TREATMENT ON ACID GASTRIC SECRETION IN ALBINO RATS
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Date
1995-03
Authors
ETTARH, REMAKE RENNER
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Abstract
The effects of gonadectomy and tamoxifen administration on
basal and histamine-stimulated gastric acid secretion in male and
females rats were studied. The effects on body and stomach
weights were also studied. Gonadectomy was performed 30 days
prior to gastric acid secretion estimation, and tamoxifen was
administered subcutaneously for 30 days before gastric acid
secretion estimation. Gastric acid output was determined by the
continuous perfusion methoi of Ghosh and Schild (1958).
Both basal and histamine-stimu1ated gastric acid secretion
in 14 castrated male rats were not significantly difference from
those in 14 tamoxifen-treated nale rats (P > 0.001). Similarly,
there was no significant difference between basal and histaminestimulated
gastric acid secretion in 14 ovariectomized rats, and
14 tamoxifen-treated female rats (p > 0.001). Basal and
histamine-Stimulated gastric Acid outputs were significantly
reduced in tamoxifen-treated male rats ( P < 0.001), bolow
the values obtained from 12 control male rats. This effect increased
as the duration of treatment was increased. In female rats, basal
and histamine-stimulated gastric acid secretion both Increased
following tamoxifen administration, above the value for 12
control female rat3 (P < 0.001). This response also increased
with increase in the duration of tamoxifen administration.
Castrated male rat3 and tamoxifen-treated male rats both
gained significantly less weight than control male rats
(P<0.001). Ovariectomized rats gained significantly more weight
than control female rats (P < 0.001). Tamoxifen-treated female
rats gained no weight throughout the period of treatment. Stomach
weights were not significantly different (P > 0.001) in either
gonadectomized or tamoxifen-trsated male and female rats.
The effect of tamoxifen on gastric acid secretion in male
rats is likely due to its antiandrogenic effect, while the result
observed in female rats may be due to its antagonism of
oestrogen. The results suggest that the susceptibility of males
and females to peptic ulceration is not greater following
tamoxifen administration than it is after castration or
ovariectomy.
Description
A THESIS
SUBMITTED TO THE
POSTGRADUATE SCHOOL
AHMADU BELLO UNIVERSITY, ZARIA
In partial fulfillment of the
requirements for the degree of
MASTER OF SCIENCE
DEPARTMENT OF HUMAN PHYSIOLOGY
FACULTY OF MEDICINE
AHMADU BELLO UNIVERSITY
ZARIA, NIGERIA
MARCH, 1995
Keywords
COMPARATIVE,, EFFECTS,, GONADECTOMY,, TAMOXIFEN,, TREATMENT,, ACID,, GASTRIC,, SECRETION,, ALBINO,, RATS.