HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF PARACETAMOL, CHLOROQUINE AND PROMETHAZINE IN SOME PHARMACEUTICAL PREPARATIONS

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dc.contributor.authorUZAMA, DANLAMI
dc.date.accessioned2014-02-19T10:36:02Z
dc.date.available2014-02-19T10:36:02Z
dc.date.issued1991-07
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICAL CHEMISTRY DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY, FACULTY OF PHARMACEUTICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA. JULY, 1991en_US
dc.description.abstractA s i n g l e s o l v e n t system was developed under t h e same c o n d i t i o n s for the a n a l y s i s of p a r a c e t a m o l, c h l o r o q u i n e and promethazine in some p h a r m a c e u t i c al p r e p a r a t i o n s (Maxiquine and Daga-Quine syrups, and Daga-Quine t a b l e t s ) using High Performance Liquid Chromatography (HPLC) Waters Model 204 f i t t e d with U.V. d e t e c t o r Model 441 with a fixed wavelength (254nm) and Model U6K s e p t u m l e s s i n j e c t o r . A pump Model 510 at a flow r a t e of 1.5ml/min, with a p r e s s u r e of 2000 PSI. The column used was a uBonda- Pak (Radial-Pak) 0-18 column (l5cm x 3.9mm I . D . ) with a mobile phase c o n s i s t i n g of a c e t o n i t r i l e : s o d i um dihydrogen phosphate : t r i e t h y l a m i n e ( 6 0 : 3 9 : l ), pH 7.2 at an ambient t e m p e r a t u r e . The r e t e n t i on times (tR) of p a r a c e t a m o l , chloroquine and promethazine were 3 . 0 , 5.8, and 12.0min. r e s p e c t i v e l y , while t h at of the i n t e r n a l s t a n d a r d s were 4.2min for a c e t o a c e t a - n i l i d e and 8.0 min. for p a p a v e r i n e , r e s p e c t i v e l y. The e x t r a c t i o n r e c o v e r i e s were 97% for p a r a c e t a m o l, and 90% for c h l o r o q u i n e and promethazine. Calibration curves were l i n e a r from 20 to 100 ug/ml (r = 0.990) f o r p a r a c e t a m o l , and 100 to 500 ug/ml (r = 0.999 and 0.990) for chloroquine and promethazine r e s p e c t i v e l y. The Maxiquine syrup contained 96%, 95% and 101% of p a r a c e t a m o l , chloroquine and promethazine r e s p e c t i v e l y. The Daga-Quine syrup contained 96.7% and 96% of paracetamol and chloroquine r e s p e c t i v e l y , while the Daga-Quine t a b l e t s contained 101% and 103% of paracetamol and chloroquine r e s p e c t i v e l y . The precision of the method was 1.7% (n = 5) within run and 1.9% (n = 5) for day-to-day run. Spectrophotometric method employed for the determination of chloroquine, paracetamol and promethazine in Maxiquine syrup gave comparable r e s u l t s with the HPLC method (100%, 100% and 97% of chloroquine, paracetamol and promethazine r e s p e c t i v e l y ).en_US
dc.identifier.urihttps://kubanni.abu.edu.ng/handle/123456789/2112
dc.language.isoenen_US
dc.subjectHIGH-PERFORMANCE,en_US
dc.subjectLIQUID,en_US
dc.subjectCHROMATOGRAPHIC,en_US
dc.subjectDETERMINATION,en_US
dc.subjectPARACETAMOL,en_US
dc.subjectCHLOROQUINE,en_US
dc.subjectPROMETHAZINE,en_US
dc.subjectPHARMACEUTICAL,en_US
dc.subjectPREPARATIONS.en_US
dc.titleHIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF PARACETAMOL, CHLOROQUINE AND PROMETHAZINE IN SOME PHARMACEUTICAL PREPARATIONSen_US
dc.typeThesisen_US
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