COMPARATIVE ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST DERMATOPHYTE ISOLATES FROM SCHOOL CHILDREN WITH TINEA CAPITIS
COMPARATIVE ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST DERMATOPHYTE ISOLATES FROM SCHOOL CHILDREN WITH TINEA CAPITIS
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Date
2006-06
Authors
MUHAMMAD, AISHA
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Abstract
Tinea capitis is a fungal infection of the scalp and hair caused by dermatophytes. It
occurs in all age groups but predominantly found in children. The antifungal activities
such as MIC, MFC and rate of kill of fluconazole, terbinafine, lauric acid and sodium
propionate alone and in admixture against dermatophyte isolates from school children
with tinea capitis in L. E. A. primary school, Mando, Kaduna, Nigeria were assessed.
T. mentagrophyte, T. tonsuran, T. rubrum, Trichophyton species M. canis, P. furfur. P.
hortei were isolated from the school children. The trichophyton species had the
highest order of prevalence (56.67%) followed by P. furfur (20%) while P. hortei was
(13.33%) and M.canis was (10%).
The Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal
Concentration (MFC) of fluconazole ranges were (0.5- 1.0mg/ml) and (1.00 -
8.00mg/ml) respectively against the test organisms. T. mentagrophyte (isolate number
18) was found to be the most resistant of the organisms that were isolated from the
school children. The order of potent activity of the test antifungal agents was
fluconazole, terbinafine, lauric acid and sodium propionate. The combination of the
test antifungal agents investigated was found to be synergistic. Terbinafine and
Sodium propionate combination produced marked synergistic action (FIC=0.57)
against the most resistant dermatophyte isolate.
Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) after 60mins contact time
produced 5.2 and 4.3 log reduction of 1.025 x 108 spores/ml of resistant T.
mentagrophyte. The combination of Terbinafine (10mg/ml) and Sodium propionate
(200mg/ml) effected 100% kill of 1.02 x108 spores/ml of resistant T. mentagrophyte
after 20 minutes contact time. Thus the use of terbinafine/ sodium propionate
combination therapy for dermatophyte infection seem promising
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY ZARIA. IN PARTIAL FULFILLMENT OF
THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF
MASTER OF SCIENCE IN PHARMACEUTICAL MICROBIOLOGY
DEPARTMENT OF PHARMACEUTICS & PHARMACEUTICAL MICROBIOLOGY
FACULTY OF PHARMACEUTICAL SCIENCES
AHMADU BELLO UNIVERSITY, ZARIA.
Keywords
COMPARATIVE,, ACTIVITIES,, ANTIFUNGAL,, AGENTS,, DERMATOPHYTE,, ISOLATES,, SCHOOL CHILDREN,, TINEA CAPITIS