COMPARATIVE ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST DERMATOPHYTE ISOLATES FROM SCHOOL CHILDREN WITH TINEA CAPITIS

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dc.contributor.authorMUHAMMAD, AISHA
dc.date.accessioned2014-03-06T08:56:08Z
dc.date.available2014-03-06T08:56:08Z
dc.date.issued2006-06
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY ZARIA. IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICAL MICROBIOLOGY DEPARTMENT OF PHARMACEUTICS & PHARMACEUTICAL MICROBIOLOGY FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY, ZARIA.en_US
dc.description.abstractTinea capitis is a fungal infection of the scalp and hair caused by dermatophytes. It occurs in all age groups but predominantly found in children. The antifungal activities such as MIC, MFC and rate of kill of fluconazole, terbinafine, lauric acid and sodium propionate alone and in admixture against dermatophyte isolates from school children with tinea capitis in L. E. A. primary school, Mando, Kaduna, Nigeria were assessed. T. mentagrophyte, T. tonsuran, T. rubrum, Trichophyton species M. canis, P. furfur. P. hortei were isolated from the school children. The trichophyton species had the highest order of prevalence (56.67%) followed by P. furfur (20%) while P. hortei was (13.33%) and M.canis was (10%). The Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal Concentration (MFC) of fluconazole ranges were (0.5- 1.0mg/ml) and (1.00 - 8.00mg/ml) respectively against the test organisms. T. mentagrophyte (isolate number 18) was found to be the most resistant of the organisms that were isolated from the school children. The order of potent activity of the test antifungal agents was fluconazole, terbinafine, lauric acid and sodium propionate. The combination of the test antifungal agents investigated was found to be synergistic. Terbinafine and Sodium propionate combination produced marked synergistic action (FIC=0.57) against the most resistant dermatophyte isolate. Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) after 60mins contact time produced 5.2 and 4.3 log reduction of 1.025 x 108 spores/ml of resistant T. mentagrophyte. The combination of Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) effected 100% kill of 1.02 x108 spores/ml of resistant T. mentagrophyte after 20 minutes contact time. Thus the use of terbinafine/ sodium propionate combination therapy for dermatophyte infection seem promisingen_US
dc.identifier.urihttp://hdl.handle.net/123456789/3342
dc.language.isoenen_US
dc.subjectCOMPARATIVE,en_US
dc.subjectACTIVITIES,en_US
dc.subjectANTIFUNGAL,en_US
dc.subjectAGENTS,en_US
dc.subjectDERMATOPHYTE,en_US
dc.subjectISOLATES,en_US
dc.subjectSCHOOL CHILDREN,en_US
dc.subjectTINEA CAPITISen_US
dc.titleCOMPARATIVE ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST DERMATOPHYTE ISOLATES FROM SCHOOL CHILDREN WITH TINEA CAPITISen_US
dc.typeThesisen_US
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