STUDIES IN THE TRANSFORMATION OF STEROIDS
STUDIES IN THE TRANSFORMATION OF STEROIDS
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Date
1968-12
Authors
SAMUEL, ADENIYI IBIYEMI
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Abstract
A series of experiments were planned to convert a steroid into
a tetracyclic triterpenoid.
As preliminary to these experiments, a number of systematic
reactions of related types and conpounds were carried out. N-Monoand
Di-alkylation of a primary aromatic amine (1-naphthy1amine)
was f i r s t carried out. Next alkylation with different alkyl groups
on different types of hydroxyl groups were conducted, Alkylation
was done with methyl and ethyl groups on phenolic as well as carboxylic
hydroxyl groups, AS podocarpic acid contains both these
types of hydroxyl groups, that was the model compound taken for
these experiments, Six out of the eight possible forms of the mone
and dialkylated products with the two different alkyl groups and the
two different hydroxyl groups of podocarpic acid were prepared and
characterized.
Three experiments were conducted to convert cholesterol into
a nor compound by removing the methylene group at C4 and converting
ring A into a six membered ether. An A/B trans rused and A/B cis
fused ether were planned. Out of t h i s , the A/B-trans fused ether
was prepared by oxidizing cholesterol to cholesteaone, further
oxidizing cholestenone to a ring A a-lactone, then reducing this
lactone to a diol and then cyclising this diol to a o-membered ether.
Description
A THESIS SUBMITTED
To The Ahmadu Bello University
For The Degree of Master of Science
in Chemistry
Department of Chemistry,
AHMADU BELLO UNIVERSITY,
Zaria, NIGERIA. December, 1968
Keywords
STUDIES,, TRANSFORMATION,, STEROIDS.