EVALUATION OF THE ANTHELMINTIC PROPERTIES OF AFZELIA AFRICANA ‘SM’ AND COMBRETUM MOLLE ‘R.BD/GON’.

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dc.contributor.authorSIMON, MALANG KAWE
dc.date.accessioned2014-02-25T13:08:33Z
dc.date.available2014-02-25T13:08:33Z
dc.date.issued2007-08
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF VETERINARY PARASITOLOGY DEPARTMENT OF VETERINARY PARASITOLOGY AND ENTOMOLOGY FACULTY OF VETERINARY MEDICINE AHMADU BELLO UNIVERSITY ZARIA. SEPTEMBER, 2007en_US
dc.description.abstractThe anthelmintic activity of partitioned fractions of crude methanolic extracts of Afzelia africana and Combretum molle stem bark were evaluated in-vivo in rats experimentally infected with Nippostrongylus braziliensis. The crude methanolic extract of the plants were obtained after extraction with absolute methanol. These were further partitioned in three solvents to obtain four fractions (i.e. petroleum ether, chloroform, N-butanol and the aqueous methanol). Phytochemical screening conducted on the extracts of both plants revealed constituents such as alkaloids, steroids, saponins, tannins, flavonoids, cardiac glycoside and carbohydrates. The extracts fractions (with the exception of petroleum ether) were tested for anthelmintic activity against Nippostrongylus braziliensis in rats. The anthelmintic activity was assessed by comparing the number of worms recovered from rats treated with the fractions to those from non-treated infected controls rats. This study considered deparasitization rate of 70 % or greater as biologically significant. Out of the eight fractions of both plants tested, the aqueous methanol of C. molle had the highest significance (P<0.05) anthelmintic activity with 86.98 % deparasitization; followed by chloroform fraction of A. africana, chloroform fraction of C. molle, N-butanol of both plants with deparasitization of 79.20 %, 75.0 %, 72.72 % respectively when the maximum tolerated dose of 1,000 mgkg‾¹ was administered. The aqueous methanol fraction of A. africana and the crude methanolic extracts of both plants produced induced a non-significant (P>0.05) deparasitization rates of 53.33 %, 62.50 % and 48.61 % respectively. The maximum tolerated dose studies on the crude methanolic extracts of both plants were conducted to determine the therapeutic dose. A dose range 10 to 1,000 mgkg‾¹ were considered practically non-toxic while 1,600 to 5,000 mgkg‾¹ were considered slightly toxic and unsafe even though failed to produce gross and histological lesions on the internal organs. Thus, this study recommends further investigations to validate their efficacy in natural or experimental infection in ruminanten_US
dc.identifier.urihttp://hdl.handle.net/123456789/2650
dc.language.isoenen_US
dc.subjectEVALUATION,en_US
dc.subjectANTHELMINTICen_US
dc.subjectAFZELIA AFRICANA ‘SM’,en_US
dc.subjectCOMBRETUM,en_US
dc.subject‘R.BD/GON’.en_US
dc.titleEVALUATION OF THE ANTHELMINTIC PROPERTIES OF AFZELIA AFRICANA ‘SM’ AND COMBRETUM MOLLE ‘R.BD/GON’.en_US
dc.typeThesisen_US
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