ISOLATION, IDENTIFICATION AND PHARMACOLOGICAL SCREENING OF THE ALKALOIDS.OF THE LEAVES OF SYNCLISIA SCABRIDA MEIRS

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dc.contributor.authorBAKO, UMARU FAROUQ
dc.date.accessioned2014-02-10T11:45:02Z
dc.date.available2014-02-10T11:45:02Z
dc.date.issued1986-10
dc.descriptionA Thesis Submitted to the Postgraduate School, Ahmadu Bello University, in Partial Fulfilment of the Requirements for the Degree of MASTER OF SCIENCE PHARMACEUTICAL CHEMISTRY) DEPARTMENT OF PHARMACEUTICALAND MEDICINAL CHEMISTRY FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY ZARIA, NIGERIA OCTOBER 1986en_US
dc.description.abstractThe leaves of Synclisia scabrida (Menispermaceae), a plant used in the treatment of gynaeco-obstetrical and mental problems in traditional medicine was investigated for its alkaloidal content. The alkaloidal fractions of the ethanolic extract of the leaves of Synclisia scabrida showed the presence of five alkaloids by TLC. Three of the alkaloids were isolated and designated as alkaloids D, E and F. Alkaloid D m.p. 276-278°C was identified as isochondodendrine from colour reactions, spectral data and methylation experiments. This is the first report of occurence of isochondodendrine in Synclisia scabrida. Alkaloid F m.p. 268-270°C was identified as cycleanine from colour reactions, spectral data and comparison with authentic sample. This is the first report of the isolation of cycleanine from the leaves of Synclisia scabrida. The colour reactions and spectral properties of alkaloid E m.p. 230-232°C have been studied. In order to obtain further information about structure, alkaloid E was methylated to the O-methyl derivative (alkaloid E-M). The spectral properties of alkaloid E-M were studied. From the available information some suggestions have beer; made regarding the structure of alkaloid E, but no definite structure could be predicted for this alkaloid. Pharmacological screening showed that alkaloid D antagonised acetylcholine induced contractions of the frog rectus abdominis tissue. It showed weak antagonism to oxytocin induced contractions of the rat uterus. Anti-psychotic tests showed that apomorphine induced stereotyped behaviour in chicks was suppressed by alkaloid D. Alkaloid E showed no effect on acetylcholine induced contractions of the frog rectus abdominis tissue but it produced a weak antagonism to ocytocin induced contractions of the rat uterus.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/943
dc.language.isoenen_US
dc.subjectISOLATION,en_US
dc.subjectIDENTIFICATION,en_US
dc.subjectPHARMACOLOGICAL,en_US
dc.subjectSCREENING,en_US
dc.subjectALKALOIDS,en_US
dc.subjectLEAVES,en_US
dc.subjectSYNCLISIA,en_US
dc.subjectSCABRIDA,en_US
dc.subjectMEIRS,en_US
dc.titleISOLATION, IDENTIFICATION AND PHARMACOLOGICAL SCREENING OF THE ALKALOIDS.OF THE LEAVES OF SYNCLISIA SCABRIDA MEIRSen_US
dc.typeThesisen_US
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