ISOLATION, IDENTIFICATION AND PHARMACOLOGICAL SCREENING OF THE ALKALOIDS.OF THE LEAVES OF SYNCLISIA SCABRIDA MEIRS
ISOLATION, IDENTIFICATION AND PHARMACOLOGICAL SCREENING OF THE ALKALOIDS.OF THE LEAVES OF SYNCLISIA SCABRIDA MEIRS
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Date
1986-10
Authors
BAKO, UMARU FAROUQ
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Abstract
The leaves of Synclisia scabrida (Menispermaceae),
a plant used in the treatment of gynaeco-obstetrical
and mental problems in traditional medicine was
investigated for its alkaloidal content.
The alkaloidal fractions of the ethanolic
extract of the leaves of Synclisia scabrida showed
the presence of five alkaloids by TLC. Three of
the alkaloids were isolated and designated as
alkaloids D, E and F.
Alkaloid D m.p. 276-278°C was identified as
isochondodendrine from colour reactions, spectral data
and methylation experiments. This is the first report
of occurence of isochondodendrine in Synclisia
scabrida.
Alkaloid F m.p. 268-270°C was identified as
cycleanine from colour reactions, spectral data and
comparison with authentic sample. This is the first
report of the isolation of cycleanine from the leaves
of Synclisia scabrida.
The colour reactions and spectral properties
of alkaloid E m.p. 230-232°C have been studied.
In order to obtain further information about structure,
alkaloid E was methylated to the O-methyl derivative
(alkaloid E-M). The spectral properties of alkaloid
E-M were studied. From the available information some
suggestions have beer; made regarding the structure
of alkaloid E, but no definite structure could be
predicted for this alkaloid.
Pharmacological screening showed that alkaloid
D antagonised acetylcholine induced contractions
of the frog rectus abdominis tissue. It showed
weak antagonism to oxytocin induced contractions
of the rat uterus. Anti-psychotic tests showed that
apomorphine induced stereotyped behaviour in chicks
was suppressed by alkaloid D.
Alkaloid E showed no effect on acetylcholine
induced contractions of the frog rectus abdominis
tissue but it produced a weak antagonism to
ocytocin induced contractions of the rat uterus.
Description
A Thesis Submitted to the Postgraduate School,
Ahmadu Bello University, in Partial Fulfilment of
the Requirements for the Degree of
MASTER OF SCIENCE PHARMACEUTICAL CHEMISTRY)
DEPARTMENT OF PHARMACEUTICALAND MEDICINAL CHEMISTRY
FACULTY OF PHARMACEUTICAL SCIENCES
AHMADU BELLO UNIVERSITY
ZARIA, NIGERIA
OCTOBER 1986
Keywords
ISOLATION,, IDENTIFICATION,, PHARMACOLOGICAL,, SCREENING,, ALKALOIDS,, LEAVES,, SYNCLISIA,, SCABRIDA,, MEIRS,