PHARMACOGNOSTIC STUDIES AND INVESTIGATION OF ANTI-INSECT ACTIVITY OF THE STEM BARK OF STEGANOTAENIA ARAL1ACEA Hochst (F. Umbelliferae)
PHARMACOGNOSTIC STUDIES AND INVESTIGATION OF ANTI-INSECT ACTIVITY OF THE STEM BARK OF STEGANOTAENIA ARAL1ACEA Hochst (F. Umbelliferae)
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Date
1997
Authors
ABUBAKAR, MUJITABA SULAIMAN
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Abstract
This study deals with the phamacognostic characters and anti-insect activity of
Steganotaenia araliacea Hochst family umbelliferae, a family not otherwise found in tropical
West Africa. This plant usually occurs as a shrub in tropical Trees. The stem bark of (his plani
is used locally in insect pest control practices. The stem bark is slightly curved and breaks easily
with short fractures leaving smooth surfaces. The bark was collected from the plant by making
longitudenal incissions on the stem.
S. araliacea selected from among ten plants used traditionally in insect pest control
because of its singnificant larvicidal activity against the larva of Culex quinquefasiatus, with
highest activity exhibited by the
n-Hexane extract with LC50 = 6 lug/ml comparable to 5.7ug/ml of nicotine a contact insecticide
A bioassay-guided chromatographic studies of the
n-Hexane extract of S. araliacea reveals that the compounds responsible for activity lies in the
non polar fractions. By a combination of column chromatography and preparative thin layer
chromatography compound "a" the substance responsible for activity was isolated. This was
shown to have an appreciable activity against adult Culex quinquefasciatus with LC50
56.2ug/cm2. The compound has no growth regulating effect on all stages of C. quinquefasicatus
life cycle but adults which emerged from a medium containing the compound were smaller than
those from the controls. Chemical and spectroscopic studies were earned out on the active
compound "a", it was found to be steroid or terpenoid.
A preliminary macroscopical and microscopical examination of S. araliacea were carried
out to establish phamiacognostic parameters for the identification of the plant.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE
SCHOOL IN PARTIAL FULFILLMENT OF THE
REQUIREMENTS OF THE DEGREE OF MASTER OF
SCIENCE (PHARMACOGNOSY) IN THE DEPARTMENT
OF PHARMACOGNOSY AND DRUG DEVELOPMENT,
AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA
Keywords
PHARMACOGNOSTIC,, STUDIES,, INVESTIGATION,, ANTI-INSECT,, ACTIVITY,, STEM,, BARK,, STEGANOTAENIA,, ARALIACEA,, F. Umbelliferae