CO-INFECTION OF HIV AND HBV AMONG PREGNANT WOMEN ATTENDING ANTE-NATAL CARE IN SOME HOSPITALS IN KADUNA METROPOLIS, NIGERIA

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dc.contributor.authorABA, HENRIETTA ONEH
dc.date.accessioned2014-02-18T10:06:35Z
dc.date.available2014-02-18T10:06:35Z
dc.date.issued2013-02
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA. IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN MICROBIOLOGY. DEPARTMENT OF MICROBIOLOGY, FACULTY OF SCIENCE, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA.en_US
dc.description.abstractThe transmission routes and some risk factors that are associated with human immunodeficiency virus (HIV) infection are also associated with hepatitis B virus (HBV) infection. The HIV-infected pregnant cohort represents a unique population and infection with HBV is considered a public health problem worldwide. This study was conducted to determine the sero-prevalence of HIV and HBV and co-infection of both viruses among pregnant women in Kaduna, Nigeria. Eight hundred (800) pregnant women attending ante-natal care in four selected hospitals were recruited for this study. Blood samples were collected and tested for presence of HIV antibodies and Hepatitis B surface antigen (HBsAg) using Determine HIV 1 and 2 rapid test kit and First Response antigen detection kits respectively. The positive HIV blood were retested using Unigold and analyzed for CD4 counts, while positive HBsAg plasma were confirmed using ELISA and tested for various markers of hepatitis B virus. Antibodies to HIV 1 and 2 were detected in 5.9% (47/800) of the pregnant women while HBsAg was detected in 3.9% (31/800) of the pregnant women. The prevalence of HIV and HBV co-infection was 0.5% (4/800). Mean CD4 count in the HIV positive pregnant women was 396 cells/μl of blood while a mean CD4 count of 299 cells/μl of blood was recorded for the HIV and HBV co-infected women. The predominant HBV markers detected among the HBV positive pregnant women was Anti-HBc (58.1%:18/31) while the least was Anti-HBs (3.2%:1/31). Test for markers of HBV indicated Anti-HBc as the most predominant (18:58.1%), while Anti-HBs was the least (1:3.2%). Both HBV and HIV were significantly associated with polygamy, blood transfusion and surgery (P< 0.05). Therefore screening for HIV and HBV during pregnancy is essential to improve ante-natal care and inform clinical management.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1873
dc.language.isoenen_US
dc.subjectCO-INFECTION,en_US
dc.subjectHIV AND HBV,en_US
dc.subjectPREGNANT,en_US
dc.subjectWOMEN,en_US
dc.subjectATTENDING,en_US
dc.subjectANTE-NATAL CARE,en_US
dc.subjectHOSPITALS,en_US
dc.subjectKADUNA METROPOLIS,en_US
dc.subjectNIGERIAen_US
dc.titleCO-INFECTION OF HIV AND HBV AMONG PREGNANT WOMEN ATTENDING ANTE-NATAL CARE IN SOME HOSPITALS IN KADUNA METROPOLIS, NIGERIAen_US
dc.typeThesisen_US
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