ANTIDIABETIC ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF METHANOLIC EXTRACTS OF DIFFERENT PARTS OF Dichrostachys cinerea (L)Wight et Arn IN STREPTOZOTOCIN INDUCED DIABETIC RATS
ANTIDIABETIC ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF METHANOLIC EXTRACTS OF DIFFERENT PARTS OF Dichrostachys cinerea (L)Wight et Arn IN STREPTOZOTOCIN INDUCED DIABETIC RATS
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Date
2014-10
Authors
AYUBA, Zaharaddeen Sullubawa
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Abstract
The study was carried out to investigate antidiabetic, antioxidant and hepatoprotective activities of different parts (Fruits, Leaves, Stem-bark and Roots) of methanol extracts of Dichrostachys cinerea (Mimosaceae) in normoglycemic and Streptozotocin induced hyperglycaemic rats at 60mg/kg body weight. Glibenclimide (1mg/kg) was used as a reference standard. Diabetic rats treated with leaves, stem-bark, and roots extracts showed a significant decrease (p<0.05) in fasting blood glucose compared with diabetic untreated. Stem-bark extracts showed the most highest decrease in fasting blood glucose after 21 days of the treatment , followed by leaves and roots while fruit extracts showed no significant (p<0.05) difference. Furthermore there was significant increase (p<0.05) in the packed cell volume (PCV) and body weight of diabetic groups treated with stem-bark, leaves and root extracts except in the diabetic group treated with fruits extract,which showed no significant increase (p>0.05). All diabetic treated groups showed significant (p<0.05) decrease in malondialdehyde (MDA), significant increase (p<0.05) in superoxide dismutase (SOD) and catalase activities with stem-back extracts showing the highest activities in superoxide dismutase and catalase followed by leaves, roots and fruits. All diabetic treated groups showed a significant reduction of aspartate amino transferase (AST) alanine amino transferase (ALT) and alkaline phosphatase (ALP) activities , Total bilirubin (TB) concentration compared to diabetic control .There was no significant (P<0.05) change in level of serum urea and creatinine in the treated group administered with stem-barks, leaves and fruit extracts of Dichrostachys cinerea. Photomicrograph of the liver and kidney of the rats showed nephrotoxic and hepatotoxic effects of the extract. These studies suggest that various parts of Dichrostachys cinerea have antihyperglycemic, antioxidants and ameliorative effects on Streptozotocin induced-diabetes mellitus.
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ANTIDIABETIC ANTIOXIDANT, HEPATOPROTECTIVE EFFECTS