SEROPREVALENCE AND MOLECULAR IDENTIFICATION OF MEASLES VIRUS IN CHILDREN (0-8 M0NTHS) PRESENTING WITH MEASLES-LIKE SYMPTOMS IN SOME HOSPITALS IN KADUNA STATE, NIGERIA

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dc.contributor.authorOLAITAN, AYORINDE ELIZABETH
dc.date.accessioned2017-01-24T11:23:26Z
dc.date.available2017-01-24T11:23:26Z
dc.date.issued2016-02
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTERS OF SCIENCE DEGREE IN MICROBIOLOGY DEPARTMENT OF MICROBIOLOGY FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractThis study determined the seroprevalence and molecular identification of Measles virus in children (0-8 months) presenting with measles-like symptoms in some hospitals in Kaduna state. A total of 273 blood samples were collected and analyzed for measles virus IgM using ELISA. An overall prevalence of 21.2% (58/273) was obtained. A prevalence of 6.5% (13/200) was obtained in children 0-8 months and 61.6% in children 9-23 months. The seroprevalence of measles virus increased with age, with a higher prevalence (61.6%) recorded in children >8 months. Higher prevalence was found in female children (27.5%) than male children (16.3%) and this difference was statistically significant, showing an association between Measles virus infection and sex (χ2 = 5.006, df = 1, P = 0.025, OR = 1.942). There was no statistically significant association with the level of parent’s education (χ2 = 1.480, df = 3, P = 0.687), parent’s occupation (χ2 = 3.146, df = 2, P = 0.207) and the number of children in the family (χ2= 0.891, df = 3, P = 0.828). With respect to children’s vaccination status and breastfeeding, there was significant association (P = 0.031, P = 0.00) respectively. The marital type of family, place of residence and household size showed no significant association with the prevalence of measles virus. However, significant association was observed in relation to mothers’ measles history (χ2 = 7.989, df = 1, P = 0.005, OR = 2.535) and mothers’ vaccination status (χ2 = 3.873, df = 1, P = 0.049, O.R = 1.791). There was significant association between MV infection and all the symptoms presented, except for vomiting, which showed no significant association (χ2 = 3.748, df = 1, P = 0.053). There was no significant association (P > 0.05) between MV infection and malaria, typhoid and pneumonia which are common childhood-illnesses with measles-like symptoms. This study recognized age, sex, vaccination, breastfeeding, mother’s vaccination status and mother’s measles history as important demographic and risk factors of measles virus infection in children.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8498
dc.language.isoenen_US
dc.subjectSEROPREVALENCE,en_US
dc.subjectMOLECULAR IDENTIFICATION,en_US
dc.subjectMEASLES VIRUS,en_US
dc.subjectKADUNA STATE,en_US
dc.titleSEROPREVALENCE AND MOLECULAR IDENTIFICATION OF MEASLES VIRUS IN CHILDREN (0-8 M0NTHS) PRESENTING WITH MEASLES-LIKE SYMPTOMS IN SOME HOSPITALS IN KADUNA STATE, NIGERIAen_US
dc.typeThesisen_US
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