PREVALENCE AND ANTIBIOTIIC SUSCEPTIBILTY PATTERN OF METHICILLIN -RESISTANT STAPHYLOCOCCUS AUREUSAMONG THE INTERNALLY DISPLACED PERSONS IN MAIDUGURI, NIGERIA

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dc.contributor.authorABDULLAHI, Hafsah Muhammad
dc.date.accessioned2017-12-21T12:41:13Z
dc.date.available2017-12-21T12:41:13Z
dc.date.issued2017-06
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCIENCE DEGREE IN MICROBIOLOGY. DEPARTMENT OF MICROBIOLOGY, FACULTY OF LIFE SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA NIGERIA.en_US
dc.description.abstractAntimicrobial resistance has been noticed as one of the paramount microbial threats in the twenty first century. Staphylococcus aureus has always been a stumbling block for antimicrobial chemotherapy and methicillin resistance of S. aureus remains to be a significant problem and a global threat to human race due to its multidrug resistance propensity and avalanche of diseases associated with it. Methicilin-Resistant Staphylococcus aureus is troublesome in homeless shelters that are crowded and confined with poor hygiene practice, (a typical of internally displaced persons camp) which may proliferate, thus putting inhabitants at increased risk of contracting MRSA. This study determined the prevalence of MRSA among the internally displaced persons (IDP) in Maiduguri, Nigeria. In this study, 400 nasal swabs were collected from IDP‘s in some selected camps within Maiduguri metropolis. The swabs were inoculated on blood agar and mannitol salt agar. Fifty one S. aureus were isolated giving a prevalence of 12.75%.The isolates were further characterised by phenotypic and molecular methods, for detection of MRSA. Out of the fifty one S. aureus isolates, 46 (90.20%) isolates were identified by Cefoxitin disc diffusion as MRSA. Eight representative of MRSA isolates were confirmed by PCR. Forty six (46) MRSA and five (5) MSSA isolates exhibited multi resistant pattern to the commonly used antibiotics. The antibiotic susceptibility test of S. aureus showed a high level of resistance to Oxacilin and Cefoxitin (90.20%) followed by Penicilin (84.31). Relatively high level of resistance was observed to Tetracycline (50.98%) but no resistance was observed to chloramphenicol and Ofloxacin. Polymerase chain reactiondetected mecA gene from the eight methicillin-resistant phenotypes which were selected randomly from the five IDP camps.The prevalence of S. aureus and MRSA isolated from nasal swab of IDPs was found to be 12.75% and 90.20% respectively.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9868
dc.language.isoenen_US
dc.subjectPREVALENCE,en_US
dc.subjectANTIBIOTIIC SUSCEPTIBILTY PATTERN,en_US
dc.subjectMETHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS,en_US
dc.subjectINTERNALLY DISPLACED PERSONS,en_US
dc.subjectMAIDUGURI,en_US
dc.subjectNIGERIAen_US
dc.titlePREVALENCE AND ANTIBIOTIIC SUSCEPTIBILTY PATTERN OF METHICILLIN -RESISTANT STAPHYLOCOCCUS AUREUSAMONG THE INTERNALLY DISPLACED PERSONS IN MAIDUGURI, NIGERIAen_US
dc.typeThesisen_US
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