EVALUATION OF THE CHEMOPREVENTIVE EFFECTS OF BALANITE AEGYPTICAAND ZIZIPHUS SPINA-CHRISTY SUPPLEMENTON N-METHYL-N-NITROSOUREA INDUCED COLON CARCINOGENESIS IN MALE WISTAR RATS

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dc.contributor.authorLABARAN, MOHAMMED SHUAIBU
dc.date.accessioned2018-11-12T10:22:11Z
dc.date.available2018-11-12T10:22:11Z
dc.date.issued2017-11
dc.descriptionA THESIS SUBMITED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER DEGREE IN LIFE SCIENCE DEPARTMENT OF BIOCHEMISTRY FACULTY OF LIFE SCIENCE AHMADU BELLO UNIVERSITY, ZARIA NIGERIA JULY2017en_US
dc.description.abstractThe colon carcinogenesis chemopreventive potential of different levels of Balanites aegyptica and Ziziphus spina-christy diets supplemented at 2.5%, 5% and 10% were examined on N-Methyl-N-Nitrosourea induced colon carcinogenesis in male wistar rats. Following ten (10) weeks of induction with N-Methyl-N-Nitrosourea (MNU) and concomitant feeding with supplemented diets, it was observed that groups on diet supplemented with Balanites aegypticaand Ziziphus spina-christyshowed a significant (p˂0.05) decrease in carcinoembryonic antigen (CEA) levels in a dose-dependent manner. There was a significant (p˂0.05) increase in the body weight of the MNU treated with 10 % Balanites aegypticaand Ziziphus spina-christy supplemented diet group. The feeding rate among the treatment groups showed no significant (p˂0.05) difference. Furthermore, there was no significant (p˂0.05) difference in white blood cell, red blood cell counts, hemoglobin concentration and platelets. The MNU treated group that the diet was supplemented with the 10% Balanites aegypticaand Ziziphus spina-christy showed significant increase in superoxide dismutase and catalase activity, while the photomicrograph of the colon of MNU control showed hyperchromiticity, atrophy of gland and necrosis compared to normal mucosal features observed in the normal control with normal colon features. These findings suggest that Balanites aegypticaand Ziziphus spina-christy especially at 10% supplementation level were able to provide a chemopreventive effect against colon carcinogenesis, probably because of their fiber, polyphenol and flavonoid contentsen_US
dc.identifier.urihttp://hdl.handle.net/123456789/10855
dc.language.isoenen_US
dc.subjectEVALUATION,en_US
dc.subjectCHEMOPREVENTIVE EFFECTS,en_US
dc.subjectBALANITE AEGYPTICA,en_US
dc.subjectZIZIPHUS SPINA-CHRISTY SUPPLEMENTON N-METHYL-N-NITROSOUREA INDUCED COLON CARCINOGENESIS,en_US
dc.subjectMALE WISTAR RATSen_US
dc.titleEVALUATION OF THE CHEMOPREVENTIVE EFFECTS OF BALANITE AEGYPTICAAND ZIZIPHUS SPINA-CHRISTY SUPPLEMENTON N-METHYL-N-NITROSOUREA INDUCED COLON CARCINOGENESIS IN MALE WISTAR RATSen_US
dc.typeThesisen_US
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