THE USE OF GLYCATED HAEMOGLOBIN IN DETERMINING GLYCAEMIC CONTROL AND ASSESSING RISK OF RENAL DAMAGE IN DIABETIC PATIENTS IN ABUTH, ZARIA
THE USE OF GLYCATED HAEMOGLOBIN IN DETERMINING GLYCAEMIC CONTROL AND ASSESSING RISK OF RENAL DAMAGE IN DIABETIC PATIENTS IN ABUTH, ZARIA
No Thumbnail Available
Date
2021-03
Authors
MUSTAFA, Ibrahim Oladayo
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Glycated haemoglobin (HbA1C) is being reported to vary in level for a given blood glucose
range from individual to individual especially along racial line. This study was therefore
carried out to investigate the local HbA1C normal level and determine extent of (if any)
variation from the World Health Organization(WHO) recommended threshold for the onset
of diabetes mellitus(DM) and pre-diabetes using blood glucose as a benchmark. And also
look into the correlation between glycated hemoglobin A1c (HbA1c) and the risk of
developing diabetic nephropathy among diabetic patients attending Ahmadu Bello University
Teaching Hospital (ABUTH) Zaria, Nigeria and determine the level or range of glycated
hemoglobin at which the risk of nephropathy becomes pronounced. One hundred and fifty
two (152) volunteer subjects were used for the study comprising of 101 diabetic subjects and
51 non-diabetic control subjects. Blood sample, 5ml, was collected from each of the subjects
after about 8 to 10 hours of overnight fasting. About 3ml of the sample was centrifuged and
the serum analysed for fasting blood glucose (FBG) and serum creatinine (SCr). The
Glomerular Filtration Rate (GFR) was then calculated from the serum creatinine values using
Cockroft-Gault equation. The remaining volume of blood, about 2ml, was transferred into
EDTA bottles and analysed immediately for glycated haemoglobin (HbA1C).Thirty-seven
(37) of the diabetic subjects and twenty-three (23) of the non-diabetic subjects had mean
HbA1C levels of 6.96% and 6.29% respectively that correspond to mean FBG levels of
91.37mg/dL and 79.16mg/dL respectively. No significant correlation was found between
HbA1c and GFR but on selecting subjects with HbA1c level ≥ 9% and testing the correlation
between their HbA1c and GFR, the correlation became significant and negatively (r= -0.35).
The glycated haemoglobin (HbA1c) levels of diabetic patients attending Ahmadu Bello
University Teaching Hospital and non-diabetic control subjects was distinctly higher for a
given blood glucose range. Also, diabetic patients with HbA1c levels ≥ 9% had a
significantly lower GFR.
Description
A DISSERTATION SUBMITTED TO THE SCHOOL OF
POSTGRADUATE STUDIES, AHMADU BELLO
UNIVERSITY IN PARTIAL FULFILLMENT OF THE
REQUIREMENTS FOR THE AWARD OF DOCTOR OF
PHILOSOPHY IN HUMAN PHYSIOLOGY
DEPARTMENT OF HUMAN PHYSIOLOGY,
FACULTY OF BASIC MEDICAL SCIENCES,
COLLEGE OF MEDICAL SCIENCES,
AHMADUBELLO UNIVERSITY,
ZARIA, NIGERIA
Keywords
USE OF GLYCATED HAEMOGLOBIN,, DETERMINING GLYCAEMIC CONTROL,, ASSESSING RISK,, RENAL DAMAGE,, DIABETIC PATIENTS,, ABUTH, ZARIA