DEVELOPMENT OF ACACIA GUM (ACACIA SEYAL) CROSSLINKS AS MATRIX IN SUSTAINED-RELEASE SALBUTAMOL SULPHATE TABLET FORMULATIONS

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dc.contributor.authorJAMES, Akila Bwala
dc.date.accessioned2019-10-03T15:12:52Z
dc.date.available2019-10-03T15:12:52Z
dc.date.issued2019-04
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICS DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL MICROBIOLOGY, FACULTY OF PHARMACEUTICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractThis study evaluated the potential of cross-linked Acacia seyal gumas matrix in sustained-release salbutamol sulphate tablet formulations prepared by direct compression method.Cross-linking which involves re-enforcing bonds with chemical bridges between molecules or polymer chains is expected to reduce the solubility of hydrophilic polymers, making them more reliable as sustained release matrix formers. The crude Acacia seyal gum was purified and labeled as ―EG‖, thencross-linked with freshly prepared 1.0 M calcium chloridesolution to obtain ―CG‖.The cross-linking was confirmed by the percentage yield, differential scanning calorimetry (DSC) and Fourier transform infra-red (FT-IR) spectrophotometry. The colour, texture, taste and odour were used to describe the organoleptic characters of the polymers, while determination of the moisture loss on drying, solubility, viscosity, swelling ratio, swelling rate, hydration capacity, pH,moisture sorption profile, particle size distribution, bulk density, tapped density, true density, flow rate, angle of repose, compressibility index and Hausner‘s ratiowere used to characterize the physicochemical and flow properties of the polymers.Directly compressed tablets were formulated, with a constant quantity of salbutamol sulphate (8 mg), while the matrix material varied between 30, 40 and 50 percent (%), resulting in formulations T1, T2 and T3 containing EG; T4, T5 and T6 containingCGand; T7, T8 and T9containinghydroxypropyl methylcellulose (HPMC) respectively. The tablets were then evaluated for various tableting properties, which include weight, diameter, thickness, friability, crushing strength, tensile strength, disintegration time,drug content and dissolution. The results showed DSC thermogramand FT-IR spectrum of CG with theappearance of new peak and new bands respectively. CG was light brown, gritty, bland and odourless. CG with low moisture content,reduced solubility in water,lower viscosity, higher swelling ratio and rate, low vii hydration capacity and higher pHwas able to sorp water and swell. The lower coarse particles,bulk density, tapped density, true density,flow rate, and angle of repose,compressibility indexand Hausner‘s ratio demonstratedgood flowability of CG. The formulated tabletshad weight, diameter, thickness, friability, crushing strength, tensile strength, disintegration time anddrug content within acceptable B.P. standards forsustained-release dosageform tablets with weight between 131 – 325 mg. Drug releasewas studied in a solution of 0.1N HCl, pH 1.0, for 2 hthen the medium changed to a buffer solution, pH 6.8, for 6 h. Cumulative percent drug releaseshowed that T50 waslonger for the CG matrices compared with the EG and HPMC matrices. Formulation T4 (30 % CG proportion) showedT50value of 2.44 h and release of 78.78 % at the 8th h, the closest release to the expected theoretical release of 66.66 %. Based on these and the statistical analysis, T4 that sustained the release of salbutamol sulphate for about 12 h was selected as the optimum formulation in this study.It is thus safe to conclude that cross-linkingAcacia seyal gum with calcium chloride imparted sustained release properties to salbutamol sulphate tablets produced by direct compression method.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/12099
dc.language.isoenen_US
dc.subjectDEVELOPMENT,en_US
dc.subjectACACIA GUM (ACACIA SEYAL),en_US
dc.subjectCROSSLINKS,en_US
dc.subjectMATRIX IN SUSTAINED-RELEASE SALBUTAMOL,en_US
dc.subjectSULPHATE TABLET FORMULATIONS,en_US
dc.titleDEVELOPMENT OF ACACIA GUM (ACACIA SEYAL) CROSSLINKS AS MATRIX IN SUSTAINED-RELEASE SALBUTAMOL SULPHATE TABLET FORMULATIONSen_US
dc.typeThesisen_US
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