EVALUATION OF CELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE PRODUCED FROM RICE HUSKS IN TABLETING
EVALUATION OF CELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE PRODUCED FROM RICE HUSKS IN TABLETING
| dc.contributor.author | MUSA, Hassan | |
| dc.date.accessioned | 2014-02-07T10:01:15Z | |
| dc.date.available | 2014-02-07T10:01:15Z | |
| dc.date.issued | 1999-03 | |
| dc.description | A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICS DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL MICROBIOLOGY, FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY, ZARIA MARCH, 1999 | en_US |
| dc.description.abstract | Cellulose and sodium carboxymethylcellulose (SCMC) derived from rice husks have been evaluated as tablet ingredients. Rice husk, an agricultural waste of the first order, found abundantly and freely, was evaluated for its high components of cellulose and as an alternative source of raw material for the synthesis of sodium carboxylic- cellulose, an important pharmaceutical necessity. Alpha-cellulose was extracted from rice husks by using standard extraction procedures which include indemnification, digestion, bleaching and washing. Part of the rice husks alpha cellulose (RHAC)so extracted and chloroplast acid were used as the main raw materials in synthesizing the SCMC. The rice husks gave and alpha cellulose yield of 23%w/w, while the alpha cellulose in turn gave yield of 92%w/w SCMC. The elucidation of the physio-chemical properties such as pharmacologist characterization, particle size and size distribution, particle shape, bulk and tapped densities, Carr's indices, moisture content, flow rate, angle of repose of the RHAC and the SCMC was undertaken. The SCMC was denser with higher flow rate than RHAC. The SCMC is a multi-purpose ingredient as well as possessing a cathartic bulk laxative property. The tablets absorbed many times its weight of water resulting in formation of gelatinous layer around the tablets which did not disintegrate even after 60 minutes. Thus the compendium limit of the disintegration time does not apply here. The stimulation of Castro intestinal tract (git) peristalsis by bulkiness and the gelatinous lubricate action of the swollen tablets are thought to produce the laxative a c t i o n . When RHAC was used as the sole excitements, the tablets had a higher bulk forming effect as compared to the conventional mufti-excipient tablet formulation used in the study. SCMC in paracetamol tablet formulation was evaluated as a disintegrate compared to maize starch, as a binder compared to gelatin and as a glidant/lubricant compared to talc/magnesium separate. The properties of SCMC were-similar to those of the compared standards and apart from the gliding/lubricant effect that was the same, the other standard excipient materials were slightly superior SCMC. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/617 | |
| dc.language.iso | en | en_US |
| dc.subject | EVALUATION, | en_US |
| dc.subject | CELLULOSE, | en_US |
| dc.subject | SODIUM, | en_US |
| dc.subject | CARBOXYMETHYLCELLULOSE | en_US |
| dc.subject | PRODUCED, | en_US |
| dc.subject | RICE, | en_US |
| dc.subject | HUSKS, | en_US |
| dc.subject | TABLETING | en_US |
| dc.title | EVALUATION OF CELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE PRODUCED FROM RICE HUSKS IN TABLETING | en_US |
| dc.type | Thesis | en_US |