EVALUATION OF CELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE PRODUCED FROM RICE HUSKS IN TABLETING
EVALUATION OF CELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE PRODUCED FROM RICE HUSKS IN TABLETING
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Date
1999-03
Authors
MUSA, Hassan
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Abstract
Cellulose and sodium carboxymethylcellulose (SCMC) derived
from rice husks have been evaluated as tablet ingredients.
Rice husk, an agricultural waste of the first order, found
abundantly and freely, was evaluated for its high components of
cellulose and as an alternative source of raw material for the
synthesis of sodium carboxylic- cellulose, an important
pharmaceutical necessity.
Alpha-cellulose was extracted from rice husks by using
standard extraction procedures which include indemnification,
digestion, bleaching and washing. Part of the rice husks alpha
cellulose (RHAC)so extracted and chloroplast acid were used as
the main raw materials in synthesizing the SCMC. The rice husks
gave and alpha cellulose yield of 23%w/w, while the alpha
cellulose in turn gave yield of 92%w/w SCMC. The elucidation
of the physio-chemical properties such as pharmacologist
characterization, particle size and size distribution, particle
shape, bulk and tapped densities, Carr's indices, moisture
content, flow rate, angle of repose of the RHAC and the SCMC was
undertaken. The SCMC was denser with higher flow rate than RHAC.
The SCMC is a multi-purpose ingredient as well as possessing
a cathartic bulk laxative property. The tablets absorbed many
times its weight of water resulting in formation of gelatinous
layer around the tablets which did not disintegrate even after
60 minutes. Thus the compendium limit of the disintegration time
does not apply here. The stimulation of Castro intestinal tract
(git) peristalsis by bulkiness and the gelatinous lubricate
action of the swollen tablets are thought to produce the laxative
a c t i o n . When RHAC was used as the sole excitements, the
tablets had a higher bulk forming effect as compared to the
conventional mufti-excipient tablet formulation used in the
study.
SCMC in paracetamol tablet formulation was evaluated as a
disintegrate compared to maize starch, as a binder compared to
gelatin and as a glidant/lubricant compared to talc/magnesium
separate. The properties of SCMC were-similar to those of the
compared standards and apart from the gliding/lubricant effect
that was the same, the other standard excipient materials were
slightly superior SCMC.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL
AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILLMENT OF THE REQUIREMENTS
FOR THE AWARD OF THE DEGREE
OF MASTER OF SCIENCE IN PHARMACEUTICS
DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL
MICROBIOLOGY, FACULTY OF PHARMACEUTICAL SCIENCES
AHMADU BELLO UNIVERSITY, ZARIA
MARCH, 1999
Keywords
EVALUATION,, CELLULOSE,, SODIUM,, CARBOXYMETHYLCELLULOSE, PRODUCED,, RICE,, HUSKS,, TABLETING