SERODIAGNOSIS OF HUMAN AFRICAN TRYPANOSOMOSIS AMONG HUMAN IMMUNODEFICIENCY VIRUS PATIENTS IN ANKPA GENERAL HOSPITAL, KOGI STATE

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dc.contributor.authorWADA, Yusuf
dc.date.accessioned2014-02-07T11:49:01Z
dc.date.available2014-02-07T11:49:01Z
dc.date.issued2012-10
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POST GRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractHuman African Trypanosomosis is a serious disease of man and animal. The present study was aimed at investigating the occurrence of Human African Trypanosomosis among Human Immunodeficiency Virus patients in Ankpa General Hospital, Kogi State. Trypanosoma brucei gambiense infection decreases the specificities of antibody detection test for HIV diagnosis. Human African Trypanosomosis symptoms are nonspecific, variable and inconsistent, and alone are insufficient for diagnosis. Moreover, HAT symptoms can be confused with those of malaria, enteric fever, tubercular meningitis and HIV. Ethical clearance was obtained from the State Ministry of Health. Blood samples were collected from HIV patients at the Ankpa General Hospital after their consent was sought. Subjects to be sampled were selected using convenience sampling with the sex, age and occupation of the HIV patients recorded. Four hundred and sixty five blood samples were collected from HIV patients. They were screened serologically using Card agglutination test for T.b gambiense (CATT) and parasitologically using the wet mount and haematocrit centrifugation technique (HCT). The overall sero-prevalence of HAT in Ankpa General Hospital among HIV patients was 3.01% (14/465). Sero-prevalence among the females and males was 3.60% (12/333) and 1.52% (2/132) respectively. There was no significant association (p>0.05) between the infection and sex. There was a sero-prevalence of 3.63% (12/330) and 2.04% (2/98) among the age groups of 18-45 years and above 45 years respectively which were not statistically significant (p>0.05). There was no significant association (p>0.05) between the infection and occupation, farmers had the highest sero-prevalence of 5.00% (10/200). No parasites were however detected in the blood samples. The questionnaire survey showed that 79.35% (369/465) of the respondents were aware of HAT and 20.64% (96/465) were not. There was a significant association (p<0.05) between education, age, occupation and awareness to HAT. There was no significant association between sex and awareness to HAT 7 (p>0.05). This study has established a serological evidence of HAT among HIV patients in Ankpa General Hospital, Kogi State. It is recommended that tsetse fly control measure should be put in place. It is also recommended that specific validation on three HIV test should be carried out to increase specificity. It is also recommended that public campaign on HAT should be carried out to increase both the awareness and knowledge of the populace to HAT in order to alert the people on the impact of the disease and how best to avoid it. 8 TABLE OFen_US
dc.identifier.urihttp://hdl.handle.net/123456789/715
dc.language.isoenen_US
dc.subjectSERODIAGNOSISen_US
dc.subjectHUMANen_US
dc.subjectAFRICANen_US
dc.subjectTRYPANOSOMOSISen_US
dc.subjectAMONGen_US
dc.subjectHUMANen_US
dc.subjectIMMUNODEFICIENCYen_US
dc.subjectVIRUSen_US
dc.subjectPATIENTSen_US
dc.subjectANKPAen_US
dc.subjectGENERALen_US
dc.subjectHOSPITALen_US
dc.subjectKOGIen_US
dc.subjectSTATEen_US
dc.titleSERODIAGNOSIS OF HUMAN AFRICAN TRYPANOSOMOSIS AMONG HUMAN IMMUNODEFICIENCY VIRUS PATIENTS IN ANKPA GENERAL HOSPITAL, KOGI STATEen_US
dc.typeThesisen_US
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