SEROPREVALENCE OF HUMAN PARVOVIRUS B19 AND HEPATITIS B SURFACE ANTIGEN AMONG PATIENTS IN SELECTED HOSPITALS IN KANO METROPOLIS, NIGERIA

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dc.contributor.authorADELOLA, JEGEDE
dc.date.accessioned2014-02-10T10:22:43Z
dc.date.available2014-02-10T10:22:43Z
dc.date.issued2013-02
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POST GRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE AWARD OF MASTERS OF SCIENCE IN MICROBIOLOGYen_US
dc.description.abstractThis study determined the seroprevalence of Human Parvovirus B19 (HPVB19) and Hepatitis B surface Antigen (HBsAg) among patients attending Aminu Kano Teaching Hospital and Hasiya Bayero Paediatric Hospital Kano. It also determined some sociodemographic factors and some possible risk factors associated with acquiring the viruses. A total of 460 blood samples were collected and analysed for HPVB19 IgG by ELISA and HBsAg using the rapid test strip. Prevalence of 41.5% (191/460) and 8.5% (39/460) was found for HPVB19 and HBsAg respectively. For HPVB19 IgG seroprevalence increased with age with the highest prevalence (51%) recorded among patients ≥51 years old while the lowest was among those < 1 year old (χ2=13.130, df=6, P=0.04). Higher prevalence was found in female (42.6%:98/230) than male patients (40.4%:93/230), though not statistically significant. With respect to occupation the highest seropositivity was observed among farmers (64.2%:18/28) while the lowest was among retired persons (27.2%:3/11). There was significantly associated between level of formal education attained and HPVB19 (χ2 =10.363, df=4, P=0.03) and number of persons living in a house (χ2 =14.303, df=1, P=0.00) respectively but no statistically significant association was observed with marital status and type of residence (P=0.3, P=0.5) respectively. History of transfusion was an important risk factor for HPVB19 transmission (OR=2.0:1; P=0.08). The seroprevalence among pregnant female patients was 41.5% (17/41). Despite the availability of a vaccine a HBsAg prevalence rate of 8.5% (39/460) was reported in this study. Patients in age group 21-30 years old had the highest prevalence of 15.5% (16/103) but the virus was not detected in patients <1 year old and seropositivity was significantly associated with age (χ 2=16.620, df=6, P=0.01). Prevalence in male patients (8.2%:19/230) did not differ significantly from prevalence in female (8.7%:20/230). In relation to marital status, level of education, type of residence and number of persons living in a house, there was no statistically significant association with Hepatitis B Virus. Similarly there was no statistically significant relationship between blood transfusion, history of jaundice, organ transplant and HBV infection among the study population. Overall, age was a significant factor in seroprevalence of both viruses in the population.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/842
dc.language.isoenen_US
dc.subjectSEROPREVALENCEen_US
dc.subjectHUMANen_US
dc.subjectPARVOVIRUSen_US
dc.subjectB19en_US
dc.subjectHEPATITISen_US
dc.subjectSURFACEen_US
dc.subjectANTIGENen_US
dc.subjectAMONGen_US
dc.subjectPATIENTSen_US
dc.subjectSELECTEDen_US
dc.subjectHOSPITALSen_US
dc.subjectMETROPOLISen_US
dc.subjectNIGERIAen_US
dc.titleSEROPREVALENCE OF HUMAN PARVOVIRUS B19 AND HEPATITIS B SURFACE ANTIGEN AMONG PATIENTS IN SELECTED HOSPITALS IN KANO METROPOLIS, NIGERIAen_US
dc.typeThesisen_US
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