TRYPANOCIDAL ACTIVITY OF SOME ORGANOTIN COMPOUNDS ON TRYPANOSOMA BRUCEI - INFECTED MICE
TRYPANOCIDAL ACTIVITY OF SOME ORGANOTIN COMPOUNDS ON TRYPANOSOMA BRUCEI - INFECTED MICE
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Date
1997-07
Authors
SHUAIBU, SHUAIBU
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Abstract
The organotin compounds dibutyltin dichloride (DBTC), diphenyltin dichioride
(DPTC), tributyltin chloride (TBTC) and triphenyltin chloride (TPTC) were tested in
Trypanosoma brucei-infected mice for trypanocidal activity. DBTC and DPTC where found
to be trypanocidal. At a dose of 10mg/kg/day(l 32uM) and 15mg/kg/day(l 75u.M) DBTC
and DPTC respectively for five consecutive days cleared the blood of the parasites.
Subinoculation of the healthy mice with the homogenates of liver, spleen, kidney and
cerebrospinal fluid (CSF) from the mice considered cured; showed 33.3%, 66.7% and
33.3% relapse following the subinoculation with homogenate of liver, spleen and CSF from
the DBTC-treated mice respectively while 50.0%, 50% and 33.3% relapses where seen
following subinoculation with homogenate of liver spleen and CSF from the DPTC-treated
mice respectively. No relapse was seen from the subinoculation of homogenate from the
kidney of both DBTC- and DPTC-treated mice
Histopathological analysis of the liver and kidney revealed abnormalities associated
with destruction of the organ integrity. No significant damage was seen in all the spleens.
These compounds (DBTC and DPTC) may be chemotherapeutically useful in the
treatment of trypanosomiasis but more is needed to be explored on the toxic effects and
none complete clearance of the T. b. brucei from all the bodily tissues of the infected mice
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSTY, ZARIA IN PARTIAL
FULFILLMENT OF THE REQUIREMENTS FOR
THE AWARD OF MASTER OF SCIENCE
IN BIOCHEMISTRY DEPARTMENT,
AHMADU BELLO UNIVERSITY,
ZARIA
Keywords
TRYPANOCIDAL,, ACTIVITY,, ORGANOTIN,, COMPOUNDS,, TRYPANOSOMA,, A BRUCEI,, - INFECTED MICE