SEROPREVALENCE OF RUBELLA VIRUS ANTIBODIES AMONG SCHOOL CHILDREN 0-10 YEARS IN JOS, PLATEAU STATE
SEROPREVALENCE OF RUBELLA VIRUS ANTIBODIES AMONG SCHOOL CHILDREN 0-10 YEARS IN JOS, PLATEAU STATE
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Date
2016-10
Authors
WAZIRI, Hyelshilni Samuel
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Abstract
Rubella disease occurs worldwide with seasonal variation and affects both the young and
elderly and may present as an acute, mild or asymptomatic illness. Infection during
early pregnancy may result in congenital rubella syndrome (CRS), stillbirth or miscarriage.
CRS often results in multiple birth defects such as heart problems, deafness and blindness
which makes rubella a leading cause of preventable congenital defects. This study aimed
to determine the seroprevalence of rubella-specific antibodies in school children 0-10 years
in Jos.
A cross-sectional descriptive study was done to determine the seroprevalence of rubella
specific antibodies, prevalence of recent rubella infection and factors associated with its
transmission in Jos. Children aged 0-10 in selected schools in Jos North and South were
studied. Serum was obtained from children and tested for IgG and IgM using ELISA.
A total of 405 children were studied with a mean age of 6.3 years (SD ± 2.5), out of which
220 (54.3%) were female and the age group, 7-8 had the most participants (113 [27.9%]).
336 (83.0%) children tested positive for rubella IgG while only 9 (2.2%) of children tested
were positive for IgM. Age ≥5 years was significantly associated with rubella seropositivity
with CI 1.01-3.08 at 95% CI and p value 0.043. There was no significant association between sex of child and rubella seropositivity. Lack of Western education was
significantly associated with rubella seropositivity among children at 95% CI (1.21-4.25)
and p value 0.009. LGA of residence was also significantly associated with rubella
seropositivity as residents of Jos North were more 10 times more likely to be have rubella
specific antibodies than residents of Jos South. None of the study participants had ever taken rubella vaccine.A large proportion of children had no antibodies and were still susceptible to rubella virus
infection. There is a need to include rubella virus vaccine in the national routine
immunization programme.
Key words : Children, ELISA, Jos, Seropositivity, Rubella
Description
A DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE
STUDIES AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA
IN PARTIAL FULFILMENT FOR THE AWARD OF THE DEGREE
MASTER IN PUBLIC HEALTH, FIELD EPIDEMIOLOGY AND LABORATORY
TRAINING PROGRAMME
DEPARTMENT OF COMMUNITY MEDICINE
AHMADU BELLO UNIVERSITY
ZARIA - NIGERIA
Keywords
SEROPREVALENCE,, RUBELLA VIRUS ANTIBODIES,, SCHOOL CHILDREN 0-10 YEARS,, JOS,, PLATEAU STATE