CALCIUM METABOLIC INDICES OF PREGNANT WOMEN WITH PROTEINURIC PRE-ECLAMPSIA AND ECLAMPSIA

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dc.contributor.authorHASSAN, MUHAMMED SHEHU
dc.date.accessioned2016-05-09T08:46:29Z
dc.date.available2016-05-09T08:46:29Z
dc.date.issued2014-04
dc.descriptionA THESIS SUBMMITED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, IN PARTIAL FULFILLMENT FOR THE AWARD OF MASTER OF SCIENCE (MSc) IN BIOCHEMISTRY DEPARTMENT OF BIOCHEMISTRY, FACULTY OF SCIENCE, AHMADU BELLO UNIVERSITY ZARIA, NIGERIAen_US
dc.description.abstractThis case control study aimed at evaluating the calcium metabolic indices of pregnant women with preeclampsia and eclampsia was conducted on pregnant women attending Ahmadu Bello University Teaching Hospital at Shika, Nigeria. A total of 60 pregnant women at gestational age of over twenty weeks were registered for the study after obtaining informed consent. The study subjects were divided into four groups: Two control groups (I-Pregnant normotensive & II-Pregnant hypertensive) and two case groups (III-Preeclampsia & IV-Eclampsia). Characteristics of each participant were recorded using a pre- tested semi-structured questionnaire after which 5 ml of venous blood was drawn for biochemical and haematological analysis. Results obtained showed Group IV had highest age group percentage of 60% followed by group I,II and III with 40%, 33.3% and 36% respectively, 40% of the pregnant women were housewives irrespective of their educational status and they survive on monthly income of less than ₦5000, All the subjects have formal education. Mean arterial blood pressure was significantly different (P <0.05) in all the study groups and mean amount of dietary intake of energy, water, calcium and vitamin E were low in all the groups compared to the RDA. Significant differences (P <0.05) were noted in most of maternal serum electrolyte concentration in the cases when compared with the control. Changes in the serum Sodium, Chloride, Potassium were not significant (P >0.05) in all the groups. Groups I and II showed no difference in levels of magnesium compared to group III and IV which is significant (P <0.05) when compared with the serum parathyroid hormone levels in both case and control groups which show high level of significant difference (P <0.05). There was significant difference in the levels of serum ionized, non-ionized and total calcium (P <0.05) between case and control groups. No significant difference was observed in serum protein levels however there was significant difference (P < 0.05) in WBC count between the case 9.26±0.88 x109/l and control 10.64±0.80 x109/l groups. There was a positive relationship between calcium and some other electrolyte in all the study groups. In conclusion, the results of our study propose that deficiency in Calcium and imbalanced electrolyte concentrations may add to the promotion or development of Preeclampsia/Eclampsia seen in pregnancy.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7840
dc.language.isoenen_US
dc.subjectCALCIUM METABOLIC INDICES,en_US
dc.subjectPREGNANT WOMEN,en_US
dc.subjectPROTEINURIC,en_US
dc.subjectPRE-ECLAMPSIA,en_US
dc.subjectECLAMPSIA,en_US
dc.titleCALCIUM METABOLIC INDICES OF PREGNANT WOMEN WITH PROTEINURIC PRE-ECLAMPSIA AND ECLAMPSIAen_US
dc.typeThesisen_US
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