CHEMOTHERAPEUTIC EFFECTS OF AMPROLIUM TOLTRAZURIL AND GANODERMA LUCIDUM IN EXPERIMENTAL COCCIDIAL INFECTION IN WARREN CHICKS
CHEMOTHERAPEUTIC EFFECTS OF AMPROLIUM TOLTRAZURIL AND GANODERMA LUCIDUM IN EXPERIMENTAL COCCIDIAL INFECTION IN WARREN CHICKS
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Date
2008-03
Authors
PAUL, Faruna
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Abstract
One hundred and forty five day–old Warren chicks were randomly divided into five groups (A, B, C, D and E). Groups B, C, D, and E were inoculated with about 27,000 sporulated Eimeria oocysts per bird at three weeks of age while group A served as the control. Oocyst production and clinical signs were monitored from day zero post inoculation. The values of packed cell volume, total plasma protein, and body weight gain were determined at regular intervals and compared with values from control group A. Three groups (C, D and E) were treated on day seven post inoculation with amprolium, toltrazuril and Ganoderma lucidum, respectively after clinical signs and maximum oocyst production were observed. The efficacy of each drug was determined based on the number of oocyst produced per gram of feces until treatment was completed. Bloody droppings, loss of appetite, somnolence and hurddling together were initially observed at day four post inoculation while packed cell volume and body weight gain were significantly (p<0.05) reduced in all infected groups. There was no significant difference (p>0.05) in the total plasma protein between the inoculated and uninoculated groups. Amprolium, totrazuril and Ganoderma lucidum used in the treatment were observed to have anticoccidial effect with toltrazuril having the strongest effect on Eimeria, followed by amprolium and Ganoderma lucidum based on the number of oocyst produced per gram of feces in each of the groups. In conclusion it could be said that the Eimeria used in the experiment was pathogenic for chickens and could be of great economic
importance to the poultry industry as it adversely affected the weight gain of the infected group. It also has an adverse effect on the packed cell volume, with little or no effect on the total plasma protein of inoculated birds. Treatment with amprolium, toltrazuril and Ganoderma lucidum showed that they all have anticoccidial effects, but toltrazuril proved to be more efficacious followed by amprolium and lastly Ganoderma lucidum.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL
AHMADU BELLO UNIVERSITY,
ZARIA, NIGERIA
IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF MASTER OF SCIENCE (M.Sc) IN VETERINARY MEDICINE
(AVIAN MEDICINE)
DEPARTMENT OF VETERINARY SURGERY AND MEDICINE,
AHMADU BELLO UNIVERSITY,
ZARIA, NIGERIA
Keywords
CHEMOTHERAPEUTIC EFFECTS OF AMPROLIUM TOLTRAZURIL,, GANODERMA LUCIDUM,, EXPERIMENTAL COCCIDIAL INFECTION,, WARREN CHICKS.