SEROPREVALENCE AND PCR DETECTION OF CHLAMYDIA TRACHOMATIS AMONG PREGNANT WOMEN AND GYNAECOLOGIC PATIENTS ATTENDING SOME TERTIARY HOSPITALS IN NORTH CENTRAL, NIGERIA

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dc.contributor.authorMUHAMMAD, Hassan Isa Doko
dc.date.accessioned2016-05-16T12:49:46Z
dc.date.available2016-05-16T12:49:46Z
dc.date.issued2015-10
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT FOR THE AWARD OF A DOCTOR OF PHILOSOPHY OF SCIENCE IN MICROBIOLOGY DEPARTMENT OF MICROBIOLOGY FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY, ZARIAen_US
dc.description.abstractThis research was undertaken to detect the presence of Chlamydia in Pregnant women and Gynaecologic patients in some Tertiary Health Care Centers in the North-Central Nigeria. Six hundred Blood and endocervical swab samples were collected and analysed by ELISA and PCR Techniques respectively. The six hundred blood blood samples were also screened for HIV infection. A structured questionnaire was used to obtain data on socio-demographic and risk factors of Chlamydia from the study participants. A sero-prevalence of 59.0% was recorded for the Hospitals sampled. The sero-prevalence was higher among the gynaecologic patients (62.0%) than the pregnant women (57.5%). The difference was statistically significant (P = 0.0001). Of the four Health Care Centers chosen for the study, the National Hospital, Abuja had the highest prevalence (84.7%), while the General Hospital, Minna, Niger State had the least (28.7%). The difference was also statistically significant (P<0.0001). The prevalence rate of HIV among the participants in the Study Centers was found to be 17.2%. The National Hospital, Abuja had the highest prevalence rate of 24.6%, followed by the Federal Medical Centre, Makurdi, 16.7%, then Federal Medical Centre Lokoja, 12.0% and finally, General Hospital, Minna, 4.7%. Chlamydia was found to be associated with HIV (p<0.0001). Teenage (P<0.0001, OR= 12.35 CI:3.48-43.73), Secondary School Educational level (P = <0.0001, OR=3.69 CI: 1.57-8.98), unskilled occupation (P= <0.0001, OR=4.22 CI: 2.19-8.12), single marital status (P = 0.0002, OR=4.96 CI: 1.98-12.43) and more than one life time partners (P = 0.02, OR=7.35 CI: 3.55-15.21) were the risk factors associated with chlamydial infection. Chlamydia was found to present asymptomatically more than with symptoms (P= <0.0001). Chlamydia was found to be associated with HIV in the study area and may have resulted in the zone emerging with the highest HIV prevalence in the Country. The chlamydial complications considered in this study (PID, ectopic pregnancy and infertility), were not found to be statistically associated ix with Chlamydia. Future studies are required to investigate the genotypes of chlamydia in circulation in the study population and to investigate the role of Chalmydia trachomatis genotypes in disease manifestations.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7884
dc.language.isoenen_US
dc.subjectSEROPREVALENCE,en_US
dc.subjectPCR DETECTION,en_US
dc.subjectCHLAMYDIA TRACHOMATIS,en_US
dc.subjectPREGNANT WOMEN,en_US
dc.subjectGYNAECOLOGIC PATIENTS ATTENDING,en_US
dc.subjectTERTIARY HOSPITALS,en_US
dc.subjectNORTH CENTRAL,en_US
dc.subjectNIGERIAen_US
dc.titleSEROPREVALENCE AND PCR DETECTION OF CHLAMYDIA TRACHOMATIS AMONG PREGNANT WOMEN AND GYNAECOLOGIC PATIENTS ATTENDING SOME TERTIARY HOSPITALS IN NORTH CENTRAL, NIGERIAen_US
dc.typeThesisen_US
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