EFFECT OF MULTIPLE INFECTIOUS BURSAL DISEASE VACCINATION ON ANTIBODY RESPONSE OF PULLETS TO NEWCASTLE DISEASE VACCINE LA SOTA AND PATHOLOGICAL CHANGES IN MAJOR IMMUNE ORGANS

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dc.contributor.authorMUHAMMAD, MUHAMMAD BABAJI
dc.date.accessioned2018-11-14T09:26:59Z
dc.date.available2018-11-14T09:26:59Z
dc.date.issued2018-02
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE AWARD OF A MASTER DEGREE IN AVIAN MEDICINE DEPARTMENT OF VETERINARY MEDICINE FACULTY OF VETERINARY MEDICINE AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractThis study was conducted with the aim of determining the effect of multiple infectious bursal disease vaccination on antibody response of pullets to Newcastle disease (ND) vaccine La Sota and pathological changes on major immune organs. A total of 120 day-old pullets were used, the birds were randomly divided into 6 groups (A, B, C, D, E and F), consisting of 20 chicks each. A freeze-dried live attenuated infectious bursal (IBD) disease vaccines, M.B. strain (ABIC) and Newcastle disease vaccine La Sota strain live virus (ABIC) were administered orally. Group A pullets were vaccinated with IBD vaccine at 1st and 2nd weeks of age. Group B pullets received IBD vaccine at 2nd and 4th weeks. Group C pullets received IBD vaccine at 3rd weeks. Group D pullets received IBD vaccine at 2nd, 4th and 6th weeks. All the groups with the exception of group F received ND vaccine at 3rd and 6th weeks. Group F pullets received no vaccine. Ten serum samples from each group in this experiment were collected for 8 weeks and tested against ND for antibodies using ELISA test. Mean Elisa ND antibody titre had indicated statistical difference at week 5, where groups B and A (P≤0.01), C and B (P≤0.01) and D and C (P≤0.05). At week 7 groups D and C (P≤0.01). The multiple IBD vaccine had negative effect on ND vaccine La Sota, group C had highest ND mean Ab titre of 11480.6 ±827.45 at week 8. The gross lesions observed were more severe in groups B and D and milder in group E and F. Histopathologically lesions were more severe in groups that where vaccinated with multiple IBD vaccines. From this work it was recommended that it is safer to give two weeks interval before repeating infectious bursal disease vaccination for Newcastle disease vaccine La Sota vaccination to be effective.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/10933
dc.language.isoenen_US
dc.subjectEFFECT,en_US
dc.subjectMULTIPLE INFECTIOUS BURSAL DISEASE VACCINATION,en_US
dc.subjectANTIBODY RESPONSE,en_US
dc.subjectPULLETS TO NEWCASTLE DISEASE VACCINE LA SOTA,en_US
dc.subjectPATHOLOGICAL CHANGES,en_US
dc.subjectMAJOR IMMUNE ORGANSen_US
dc.titleEFFECT OF MULTIPLE INFECTIOUS BURSAL DISEASE VACCINATION ON ANTIBODY RESPONSE OF PULLETS TO NEWCASTLE DISEASE VACCINE LA SOTA AND PATHOLOGICAL CHANGES IN MAJOR IMMUNE ORGANSen_US
dc.typeThesisen_US
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