THE EFFECT OF RANITIDINE ON THE ABSORPTION AND PHARMACOKINETICS OF PRAZIQUANTEL IN SCHISTOSOMA HAEMATOBIUM -INFECTED SUBJECTS
THE EFFECT OF RANITIDINE ON THE ABSORPTION AND PHARMACOKINETICS OF PRAZIQUANTEL IN SCHISTOSOMA HAEMATOBIUM -INFECTED SUBJECTS
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Date
1994-12
Authors
UMAR, MUSA
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Abstract
Praziquantel tablets were assayed for content of active ingredient. Tests for disintegration
and dissolution were carried out. The results complied with the official specifications for
praziquantel tablets. The dissolution rates were however lower at pH 6.8.
The effect of ranitidine, ISOmg on the mean absorption and pharmacokinetics of
praziquantel following single dose of 40mg/kg was studied in six Schistosoma
haematobiutn-'mi'ecied subjects. The study was conducted in a crossover experimental
design in which ranitidine was given one hour prior to praziquantel administration.
Pharmacokinetic parameters were derived from the praziquantel plasma concentration -
time profiles of subjects using PCNONLIN non linear estimation program. The
pharmacokinetic data obtained were compared using the student t-test: paired - two
sample for means and values of p<0.05 were considered statistically significant and values
of p>0.05 were considered statistically not significant. Ranitidine co-administration caused
statistically significant changes in Cmax, Kabs and Tlag (P<0.001, P<0.05 and PO.05
respectively). The change in Tmax was however not significant (P<0.5).
The effect of ranitidine on Tl/2, Kel, and the AUC was also significant (PO.01, P<0.01
and P- 0.001 respectively). The total systemic clearance increased significantly (p<0.01).
This may suggest that the liver may not be the only site of antiquarian pre-systemic
elimination. Considerable information can therefore be obtained from measuring both
drug and metabolites alter drug administration, although using mean pharmaceutical
values may be misleading and should be cautiously interpreted especially where
quantitative aspects of drug metabolism are concerned
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU
BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILLMENT OF THE
REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE IN
PHARMACEUTICAL ANALYSIS
DEPARTMENT OF PHARMACEUTICAL AND
MEDICINAL CHEMISTRY
FACULTY OF PHARMACEUTICAL SCIENCES
AHMADU BELLO UNIVERSITY
ZARIA, NIGERIA
DECEMBER, 1994
Keywords
EFFECT,, RANITIDINE,, ABSORPTION,, PHARMACOKINETICS,, SCHISTOSOMA,, HAEMATOBIUM,, -INFECTED,, SUBJECTS