THE EFFECT OF RANITIDINE ON THE ABSORPTION AND PHARMACOKINETICS OF PRAZIQUANTEL IN SCHISTOSOMA HAEMATOBIUM -INFECTED SUBJECTS

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Date
1994-12
Authors
UMAR, MUSA
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Abstract
Praziquantel tablets were assayed for content of active ingredient. Tests for disintegration and dissolution were carried out. The results complied with the official specifications for praziquantel tablets. The dissolution rates were however lower at pH 6.8. The effect of ranitidine, ISOmg on the mean absorption and pharmacokinetics of praziquantel following single dose of 40mg/kg was studied in six Schistosoma haematobiutn-'mi'ecied subjects. The study was conducted in a crossover experimental design in which ranitidine was given one hour prior to praziquantel administration. Pharmacokinetic parameters were derived from the praziquantel plasma concentration - time profiles of subjects using PCNONLIN non linear estimation program. The pharmacokinetic data obtained were compared using the student t-test: paired - two sample for means and values of p<0.05 were considered statistically significant and values of p>0.05 were considered statistically not significant. Ranitidine co-administration caused statistically significant changes in Cmax, Kabs and Tlag (P<0.001, P<0.05 and PO.05 respectively). The change in Tmax was however not significant (P<0.5). The effect of ranitidine on Tl/2, Kel, and the AUC was also significant (PO.01, P<0.01 and P- 0.001 respectively). The total systemic clearance increased significantly (p<0.01). This may suggest that the liver may not be the only site of antiquarian pre-systemic elimination. Considerable information can therefore be obtained from measuring both drug and metabolites alter drug administration, although using mean pharmaceutical values may be misleading and should be cautiously interpreted especially where quantitative aspects of drug metabolism are concerned
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICAL ANALYSIS DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY ZARIA, NIGERIA DECEMBER, 1994
Keywords
EFFECT,, RANITIDINE,, ABSORPTION,, PHARMACOKINETICS,, SCHISTOSOMA,, HAEMATOBIUM,, -INFECTED,, SUBJECTS
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