EPIDEMIOLOGY AND MANAGEMENT OF DIABETES MELLITUS IN ZARIA URBAN AREA
EPIDEMIOLOGY AND MANAGEMENT OF DIABETES MELLITUS IN ZARIA URBAN AREA
| dc.contributor.author | SANUSI, RABI RAFINDADI | |
| dc.date.accessioned | 2014-03-31T11:05:53Z | |
| dc.date.available | 2014-03-31T11:05:53Z | |
| dc.date.issued | 1989-08 | |
| dc.description | A thesis submitted to the Postgraduate School, Ahmadu Bello University, in partial fulfillment of the requirements for the degree of Mater of Science DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACY FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY, ZARIA | en_US |
| dc.description.abstract | Studies on the epidemiology end control of diabetes mellitus among the patients of ABUTH, Zaria were carried out. Patient understanding of the disease and compliance with treatment and other control measures were assessed through direct questioning, and by detecting the concentration of one of the oral hypoglycaemic agents (chlorpropamide) used by majority of the patients, in their blood. Samples of chlorpropamide tablets were obtained from some patients. The amount of active ingredients present were determined by standard assay techniques in order to determine the quality of drugs used by the patients. The result 6 of the study reveal that many patients lacked the understanding of their disease and the importance of proper management. This ignorance was attributed to the fact that many of the patien's had no formal education and also to the limited number of doctors at the clinic, a factor which limited the individual patient education. Appearance of some diseases and comnlications in some of the patients studied was related to their ignorance and lack of patient compliance with treatment. It was observed that regular clinic attendance was variable. Those who were not regular were often readmitted with relapse of symptoms or complication of the disease. The majority of the patients were not following a planned diet. This was because many of them were poor and so could not afford the ideal diabetic diet. This poverty and ignorance also limited the Individual control monitoring of diabetes by testing urine (and blood) for presence of sugar. For these reasons the patients were not able to adjust their diet and medication and so could not achieve good control. The result of the tablet assay showed that 2 of the 5 brands of the tablets tested did not comply with official (B.P.) requirement. Failure to achieve good control in some of the patients studied could also therefore be attributed to consumption of substandard or faked drugs. Serum chlorpropamide levels in 54 patients was detected using the method of Carmichael (1959) and the result shows that majority of the patients had levels within the therapeutic range. Interindividual differences as expected were observed in the serum concentration of the drug in the patients used for the study. Differences in metabolising capacity and renal excretion were suggested to be responsible for this. Two patients had serum levels well in the toxic range while a few others achieved only subtherapeutic levels. In conclusion, our data suggest that a significant number of diabetic patients in Zaria urban area lacked the understanding of their disease and this is related to their illiteracy, poverty and also to the inadequate number of medical personnel at the hospitals to educate the patients properly. The loss of control of diabetes in some patients was probably also due to noncompliance with treatment on the port of some patients and consumption of substandard drugs in addition to the above factors. It is suggested that the Diabetic Clinic in Zaria needs the services of a dietician as well as more medical personnel. The Pharmacy Shop within the hospital should always stock antidiabetic drugs of adequate standards to reduce the risk of patients buying faked, substandard or expired drugs from other places. A booklet titled % Living w i t h D i a b e t e s ' , and its Hausa translation, 'Rayuwa da c u t a r s u k a r ' , primarily directed at the diabetic has been prepared as part of this effort, | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/4518 | |
| dc.language.iso | en | en_US |
| dc.subject | EPIDEMIOLOGY, | en_US |
| dc.subject | MANAGEMENT, | en_US |
| dc.subject | DIABETES, | en_US |
| dc.subject | MELLITUS, | en_US |
| dc.subject | ZARIA URBAN AREA | en_US |
| dc.title | EPIDEMIOLOGY AND MANAGEMENT OF DIABETES MELLITUS IN ZARIA URBAN AREA | en_US |
| dc.type | Thesis | en_US |