ASSESSMENT OF THE RELATIONSHIP BETWEEN FOETAL HAEMOGLOBIN LEVELS, TISSUE DESTRUCTION AND DISEASE SEVERITY IN INDIVIDUALS WITH SICKLE CELL ANAEMIA

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dc.contributor.authorISHAYA, YUSUF DOGONZO
dc.date.accessioned2018-11-14T08:28:31Z
dc.date.available2018-11-14T08:28:31Z
dc.date.issued2018-02
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIRMENTS FOR THE AWARD OF MASTER DEGREE IN BIOCHEMISTRY DEPARTMENT OF BIOCHEMISTRY, FACULTY OF LIFE SCIENCES AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractSickle-cell Anaemia is a genetic disorder that leads to the production of Sickle haemoglobin, whichresults in abnormal functions of the red blood cell under hypoxic conditions.The aim of this study was to assess the relationship between Foetal haemoglobin, markers of tissue destruction and disease severity among individuals with sickle cell anaemia. Thirty seven adults with sickle cell anaemia with average age of 26.24±7.32 years were enrolled in this study. Twenty four of them were females while thirteen were males. Participants enrolled were individuals attending clinic at Haematology Department, Ahmadu Bello University Teaching Hospital Zaria who have been diagnosed with Sickle cell anaemia and were confirmed by cellulose acetate electrophoresis. Foetal haemoglobin was assayed using betke‟s alkali denaturation method and complete blood count was done using automated haematology analyzer. Lactate dehydrogenase (LDH) activity and bilirubin concentration were determined by spectrophotometric method while disease severity was computed based on the scores obtained from the clinical and haematological data. From our findings, there was a significant difference (P<0.05) in foetal haemoglobin (HbF) levels and LDH activity between individuals in steady state and those in crises condition. Also there was a significant inverse correlation between HbF levels and LDH activity (P= 0.01, r=-0.59) and between LDH activity and disease severity (P=0.01, r=0.42) but there was no significant (P>0.05) relationship between HbF levels & disease severity (P = 0.69, r = -0.07) and HbF levels & bilirubin concentration (P=0.78, r=-0.05).Therefore the present study suggested that HbF level has an inverse relationship with disease severity and tissue destruction. However, disease severity has a direct relationship with tissue destruction.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/10923
dc.language.isoenen_US
dc.subjectASSESSMENT,en_US
dc.subjectRELATIONSHIP,en_US
dc.subjectTISSUE DESTRUCTION AND DISEASE SEVERITY,en_US
dc.subjectINDIVIDUALS,en_US
dc.subjectSICKLE CELL ANAEMIAen_US
dc.titleASSESSMENT OF THE RELATIONSHIP BETWEEN FOETAL HAEMOGLOBIN LEVELS, TISSUE DESTRUCTION AND DISEASE SEVERITY IN INDIVIDUALS WITH SICKLE CELL ANAEMIAen_US
dc.typeThesisen_US
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