PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF THE LEAVES OF COMMIPHORA KERSTINGII Engl (Burseraceae)

Simple item page
dc.contributor.authorSALLAU, MUHAMMAD SANI KARAYE
dc.date.accessioned2015-11-30T08:58:27Z
dc.date.available2015-11-30T08:58:27Z
dc.date.issued2009-08
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, IN PARTIAL FUFILLMENT OF THE REQUIREMENT FOR DEGREE OF DOCTOR OF PHILOSOPHY (PHARMACEUTICAL AND MEDICINAL CHEMISTRY) DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY, FACULTY OF PHARMACEUTICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA-NIGERIAen_US
dc.description.abstractChemical and pharmacological investigations were carried out on the leaves of Commiphora kerstingii (Engl). The plant belongs to the family of Bursaraceae, which consists of about 17 genera and over 600 species of tropical shrubs and trees. It is of extensive ethnomedical usage. In particular it is used as a stomachic, in the treatment of inflammation of the eyes, scorpion bites, diarrhea and dysentery. Preliminary phytochemical studies carried out on the leaves revealed the presence of alkaloids, carbohydrates, flavonoids, saponins, steroids and tannins in the crude acetone extract and generally to a lesser extent in the methanol extract. This result is in good agreement with earlier reports on the stem bark of the plant. The acute toxicity studies have suggested that the acetone extract is slightly more toxic (LD50 of 2154.10mg/kg in mice) than the methanol extract (LD50 > 5000mg/kg). The pharmacological investigations indicate that both extracts of the plant leaves particularly that of acetone, exhibited effective anti-nociceptive (peripheral), anti-inflammatory and anti-oxidant properties. The acetone extract also exhibited a broad spectrum of activity against both gram-negative and gram-positive bacteria. The results also show that even some bacteria that have a higher intrinsic multi-drug resistance to most anti-microbial agents were found to be susceptible to particularly the acetone extract. Extensive phytochemical studies resulted in the isolation and characterization of two isomeric pentacyclic triterpenoids as Glutinol and Rhoiptelenol in addition to 11-methoxy--Boswellic acid from the acetone fraction of the leaves of the plant. This is the first time in history that these compounds are being reported in Commiphora species. Structure elucidation of the compounds were carried out with the help of MS, and GC/MS Spectrometry as well as IR, 1HNMR 13CNMR, 2DNMR; 1H-1HCOSY, 1H-1H long range COSY, HMQC and HMBC Spectroscopy. The anti-nociceptive and anti-inflammatory properties of the acetone extract are attributable to the presence of these triterpenoids. Generally, results from these investigations show that the plant leaves of Commiphora kerstingii are rich with bioactive compounds and could therefore be potential sources of compounds that are effective analgesics, anti-inflammatory agents and or with higher potency against most gram-positive and gram-negative bacteria.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7229
dc.language.isoenen_US
dc.subjectPHYTOCHEMICAL,en_US
dc.subjectPHARMACOLOGICALen_US
dc.subjectSTUDIES,en_US
dc.subjectLEAVES,en_US
dc.subjectCOMMIPHORA,en_US
dc.subjectKERSTINGII Engl (Burseraceae)en_US
dc.titlePHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF THE LEAVES OF COMMIPHORA KERSTINGII Engl (Burseraceae)en_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF THE LEAVES OF COMMIPHORA KERSTINGII Engl (Burseraceae).pdf
Size:
6.87 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.58 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
SCIENCE