EFFECTS OF CONTINUOUS CONSUMPTION OF ROSELLE (HIBISCUS SABDARIFFA) CALYX EXTRACT (ZOBORODO) IN HYPERTENSIVE AND NON-HYPERTENSIVE CONDITIONS

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Date
1998-03
Authors
AJANl, EMMANUEL OLADIPO
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Abstract
The LD5() of rose lie ealyx extract was determined in mice. Different doses of the extract (125-2000mg/kg body weight) were administered to different groups of normotensive and spontaneously hypertensive rats continuously for 60 days. The body weight (b.wt), blood pressure (systolic and diastolic), water and urinary volume and colouration were periodically monitored during the period of administration of the extract, serum glucose, cholesterol, creatinine, uric acid and proteins were also measured after 30 and 60 days of continuous administration of the extract. Roselle calyx extract ("zoborodo") was observed to significantly (P<O.05) lower both systolic and diastolic pressure in both normotensive and hypertensive rats at all tested doses. The reduction of blood pressure in both groups positively correlated with body weight. Continuous administration of the extract at lOOOmg/kg b.wt was observed to lead to sudden death in spontaneously hypertensive rats but not in normotensive Wistar-Kyoto rats. Water intake and urinary output was found not to be significantly different in the hypertensive control (untreated) group from the normotensive control (untreated group). The water intake was however, observed to be significantly (P<O.05) lowered in all the treated groups (hypertensive and normotensive) compared with the control (untreated), while the urinary output was significantly higher in the treated hypertensive group compared with the control. After 60 days of continuous administration of the extract, there was a significant (P<O.05) increase in serum uric acid at all tested doses in both treated hypertensive and normotensive groups compared with the controls. The serum cholesterol was significantly lower while the serum glucose was significantly higher (at doses > 500mg/kg b.wt) in all the treated rats compared with the control after 60 days of continuous treatment. Though a trend seems to be established, the serum albumin was not significantly (P>O.05) different in the treated groups compared with the control. The serum total protein, however, was found to be significantly (P<0.05) higher after 60 days treatment period in the hypertensive group treated with 500mg/kg b.wt dosage compared with the control.
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A THESIS SUBMITTED TO THE POST GRADUATE SCHOOL, AI1MADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILLMENT OF THE AWARD OF MASTER OF SCIENCE (M.Sc) DEGREE IN BIOCHEMISTRY MARCH 1998
Keywords
EFFECTS,, CONTINUOUS,, CONSUMPTION,, ROSELLE,, (HIBISCUS SABDARIFFA), CALYX,, EXTRACT,, ZOBORODO), HYPERTENSIVE,, NON-HYPERTENSIVE,, CONDITIONS
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