ASSESSMENT OF THE RELATIONSHIP BETWEEN SOME TRACE ELEMENTS AND ANTIOXIDANT ENZYMES IN UNDER-FIVE CHILDREN WITH PROTEIN-ENERGY MALNUTRITION

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dc.contributor.authorNJOKU, STELLA UJUNWA
dc.date.accessioned2016-04-21T11:32:29Z
dc.date.available2016-04-21T11:32:29Z
dc.date.issued2014-11
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTERS OF SCIENCE DEGREE IN BIOCHEMISTRY DEPARTMENT OF BIOCHEMISTRY FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY ZARIAen_US
dc.description.abstractAssessment of the relationship between some trace elements and antioxidant enzymes was carried out on 98 under-five children with protein-energy malnutrition (PEM) and 98 age- and sex-matched apparently healthy children (control). The malnourished children involve those with Marasmus, Kwashiorkor and Marasmic-kwashiorkor. Venous blood (2ml) was collected from both PEM children and control for biochemical analysis using standard methods. Results obtained show that mean serum total protein (55.76±3.95) and albumin (26.43±2.78) levels and superoxide dismutase (SOD) (1.87±0.32) and glutathione peroxidase (GPx) (42.38±5.03) activities in malnourished children were significantly lower (p<0.05) than in the control. Mean serum zinc (Zn) concentrations (8.37±4.25) in malnourished children were significantly higher (p<0.05) than in the control (5.14±2.39), but mean serum copper (Cu) concentrations in malnourished (2.40±1.12) children were lower than in the control (2.82±1.18). There were correlations between these serum levels of trace elements (Zn and Cu) and antioxidant enzymes (SOD and GPx) in children with PEM and control. Marasmus (SOD-Zn: 0.03, SOD-Cu: 0.16, GPx-Zn: -0.14, GPx-Cu: 0.05), kwashiorkor (SOD-Zn: -0.39, SOD-Cu: -0.39, GPx-Zn: -0.54, GPx-Cu: -0.31), marasmic-kwashiorkor (SOD-Zn: -0.31, SOD-Cu: -0.51, GPx-Zn: -0.41, GPx-Cu: -0.48) and control (SOD-Zn: 0.12, SOD-Cu: 0.07, GPx-Zn: -0.07, GPx-Cu: -0.08). This study points to the fact that children with PEM are predisposed to high oxidative stress due to an increase in free radical production and decrease in antioxidant defense system. Therefore, routine laboratory investigation of antioxidants should be done for effective management of PEM.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7737
dc.language.isoenen_US
dc.subjectASSESSMENT,en_US
dc.subjectRELATIONSHIP,en_US
dc.subjectTRACE ELEMENTS,en_US
dc.subjectANTIOXIDANT,en_US
dc.subjectENZYMES,en_US
dc.subjectUNDER-FIVE CHILDREN,en_US
dc.subjectPROTEIN-ENERGY,en_US
dc.subjectMALNUTRITION.en_US
dc.titleASSESSMENT OF THE RELATIONSHIP BETWEEN SOME TRACE ELEMENTS AND ANTIOXIDANT ENZYMES IN UNDER-FIVE CHILDREN WITH PROTEIN-ENERGY MALNUTRITIONen_US
dc.typeThesisen_US
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