DYNAMIC MODEL DEVELOPMENT AND RECEDING HORIZON CONTROL OF BLOOD GLUCOSE CONCENTRATION
DYNAMIC MODEL DEVELOPMENT AND RECEDING HORIZON CONTROL OF BLOOD GLUCOSE CONCENTRATION
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Date
2018-03
Authors
IBRAHIM, Abdul-Alim Gambo
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Abstract
Biological systems usually consist of large number of components and involve processes at
a variety of spatial, temporal and biological scales. This study presents a framework for
model identification and the use of Global Sensitivity Analysis (GSA) in systems biology
modelling and shows how the information content of clinical data from Short Insulin
Tolerance Test (SITT) can be handled by optimal model-based estimation techniques. The
goal is to identify dynamic model of type II diabetes and estimate a set of parameters of the
model with greater accuracy and precision. Based on the SITT data, the blood glucose
dynamic model was identified as a system of linear differential equation with constant
coefficients (parameters). The sensitivity of the parameters was tested using a novel GSA
based approach, and Derivative-Based Global Sensitivity Measures (DGSM). The proposed
approach was implemented in SensSB (a Matlab based toolbox). For the purpose of
comparison, the sensitivity of the model was also tested using Sobol’s method and a local
approach. The results have shown that the model is less sensitive to the third parameter ( )
and the model fits the SITT data satisfactorily. Subsequently, a control strategy called
receding horizon control was investigated to regulate blood glucose concentration under the
model predictive control framework. Two forms of receding horizon control strategy (fixedend
and moving-end) were proposed and applied to the dynamic model to maintain blood
glucose concentration. Different disturbance scenarios were generated to evaluate the
performance of the two strategies in terms of its efficiency to handle disturbances. The
control strategies successfully addressed the issues of the input/external disturbance
considered for the patients in a virtual situations which maintain blood glucose level at 80.06
mg/dL.
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Description
A THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE
STUDIES,
AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF
MASTER OF SCIENCE DEGREE IN CHEMICAL ENGINEERING
DEPARTMENT OF CHEMICAL ENGINEERING,
FACULTY OF ENGINEERING
AHMADU BELLO UNIVERSITY, ZARIA
NIGERIA
Keywords
DYNAMIC MODEL DEVELOPMENT,, RECEDING HORIZON CONTROL,, BLOOD GLUCOSE CONCENTRATION