THE EFFECT OF RANITIDINE ON THE ABSORPTION KINETICS OF METRONIDAZOLE
THE EFFECT OF RANITIDINE ON THE ABSORPTION KINETICS OF METRONIDAZOLE
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Date
1993-04
Authors
RAFINDADI, ABDURRAHMAN YUNUSA
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Abstract
The effect of a singleoral dose of ranitidine
I50mg was s t u d i e d on t h e a b s o r p t i o n and pharmacokinetic
parameters of metronidazole following a s i n g l e o r al
dose of 4OOmg in four h e a l t h y v o l u n t e e r s (age 28-35,
weight 50-65kg) administered one hour a f t e r r a n i t i d i ne
i n a c r o s s - o v e r s t u d y.
The a d m i n i s t r a t i o n of r a n i t i d i n e l50mg an hour
b e f o r e the dose of metronidazole did not a f f e ct
s i g n i f i c a n t l y the mean a b s o r p t i o n and pharmacokinetic
parameters of metronidazole ( p > 0 . 5 ) . Ranitidine
i n c r e a s e d Kabs by 20.5%, t1 / 2 by 10.15%, Tiag by 60.8%
and d e c r e a s e d Tmax and Cmax by 7% and 3,kh% r e s p e c t i v e ly
( i n a l l cases P > 0 . 0 5 ) . S i m i l a r l y , Kel and ClTBC were
d e c r e a s e d by 8.11% and 1.1% (P> 0 . 1 and > 0.5
r e s p e c t i v e l y ) while t1/2, Vd and AUC were i n c r e a s e d by
8.26%, 6.8% and 1.92% r e s p e c t i v e l y ( P > 0 . 1 , > 0.5 and
> 0 . 5 ) .
S i m i l a r t o r e s u l t s obtained i n previous s t u d i e s,
t h e r e were v a r i a t i o n s in t h e plasma c o n c e n t r a t i o n s and
p h a r m a c o k i n e t i c parameters of metronidazole in man.
The e f f e c t of r a n i t i d i n e on t h e k i n e t i c s of metronidazole
was h i g h l y v a r i a b l e and in some v o l u n t e e r s it was
s u b s t a n t i a l . It i s concluded t h a t d e s p i t e the l a r ge
i n t e r - i n d i v i d u a l d i f f e r e n c e s , r a n i t i d i n e does not a l t er
the mean pharmacokinetics of metronidazole in man,
but that simply using the mean data for comparison
could be misleading.
Description
DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY,
FACULTY OF PHARMACEUTICAL SCIENCES,
AHMADU BELLO UNIVERSITY,
ZARIA, NIGERIA.
APRIL, 1993
Keywords
EFFECT,, RANITIDINE,, ABSORPTION,, KINETICS,, METRONIDAZOLE