EFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICE

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dc.contributor.authorALEMIKA, EBUNOLUWA BONIRE
dc.date.accessioned2017-07-31T09:09:17Z
dc.date.available2017-07-31T09:09:17Z
dc.date.issued2016-08
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTERS DEGREE IN PHARMACOLOGY DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS, FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractMalaria is the 2nd leading cause of death from infectious diseases in Africa, after HIV/AIDS. It is a major public health problem in Nigeria where it accounts for most cases of hospital visits and deaths than any other country in the world. This study evaluated the effects of co-administration of promethazine and Artemether-Lumenfantrine in mice infected with Plasmodium berghei berghei. The mice were grouped into six groups of 6 mice each. Group 2 – 6 were inoculated with Plasmodium berghei berghei groups. Drug administration was carried out orally and for 5 days, 72 hours after parasite inoculation and parasitaemia seen. The mice were sacrificed on the 8th day. Blood samples were collected and organs harvested for haematological and histopathological evaluations. Parameters evaluated include average parasitaemia inhibition, haematological indices, organ-body weight ratio and liver transaminases. The liver, kidney and heart were subjected to histological evaluation. The result showed that promethazine alone had no significant parasitaemia inhibition but the co-administration of promethazine (both 25 mg/kg and 50 mg/kg) and artemether-lumenfantrine gave a marginal reduction but not a significant one compared to Artemether-lumenfantrine alone. Promethazine showed a significant reduction in Haemoglobin, Pack cell volume, RBC, and increase in neutrophils compared to Artemether-Lumenfantrine alone, but no effects compared to the infected control. Its co-administration of promethazine (25 mg/kg) with Artemether-Lumenfantrine gave a marginal reduction, but not a significant difference in Hb, PCV and RBC. The 50mg/kg dose of promethazine co-administered with artemether-lumenfantrine gave lower values of PVC, Hb, RBC than the 25mg/kg promethazine dose plus artemether-lumenfantrine. The liver transaminases were significantly (p≤0.05) increased for Promethazine co-administered with artemether-lumenfantrine compared to Artemther-lumenfantrine alone, although the values of AST, ALT and ALP were still mostly within the normal ranges ( AST-20-298U/l, ALT-17-80U/l, ALP-30-110U/l). Histology sections of the liver showed slight increase in hepatic congestion and lymphocyte hyperplasia, renal sections showed no significant changes while the heart sections showed slight lymphocyte hyperplasia. The study showed that co-administration of Promethazine and Artemether-lumenfantrine possesses no advantage over Artemether-Lumenfantrine alone and it has tendencies of toxicity with continuous use.en_US
dc.identifier.urihttps://kubanni.abu.edu.ng/handle/123456789/9120
dc.language.isoenen_US
dc.subjectEFFECTS,en_US
dc.subjectARTEMETHER-LUMEFANTRINEen_US
dc.subjectCO-ADMINISTRATION OF PROMETHAZINE,
dc.subjectberghei berghei INFECTED MICE
dc.titleEFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICEen_US
dc.typeThesisen_US
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