STUDIES INVOLVING INTERACTION BETWEEN ALPHAMETHYLDOPA AND COWPEA (VIGNA SINENSIS) USING BOTH NORMOTENSIVE . AND SPONTANEOUSLY HYPERTENSIVE RATS.
STUDIES INVOLVING INTERACTION BETWEEN ALPHAMETHYLDOPA AND COWPEA (VIGNA SINENSIS) USING BOTH NORMOTENSIVE . AND SPONTANEOUSLY HYPERTENSIVE RATS.
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Date
1980-11
Authors
KOLAWOLE, SIMEON OLATUNDE
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Abstract
The effect of cowpea and its possible interactions
with alphamethyldopa on the b.p. and heart
rate of normotensive and spontaneously hypertensive
rats have been studied.
ii ) Cowpea (60%w/w of Pfizer feed) increased the
b.p. of normotensive rats (NTR), but had no such
effect on spontaneously hypertensive rats (SHR).
In addition the heart rate of SHR was significantly
elevated while that of NTR was not affected. The
sympathomimetic agents further elevated the b.p.
in the NTR than in the controls, but the b.p. elevation
in the SHR was much lower than in the controls.
The heart rate of both NTR and SHR were not consistently
affected.
lii) Cowpea (20%w/w of Pfizer feed) did not alter the
b.p. of NTR, but increased the heart rate. On the
other hand, the b.p. of SHR was reduced, while the
heart rate was apparently not affected. Noradrenaline
and tyramine elevated the b.p. of this group
lower than in controls, particularly with the SHR.
The results obtained with other sympathomimetics
on both NTR and SHR were not consistent.
iv) Alphamethyldopa did not alter the b.p. of the NTR
but lowered that of SHR. The heart rate uf both
NTR and SHR was significantly elevated by alphamethyldopa.
The b.p. elevating effect of the
sympathomimetics were not significantly more than
those obtained in the controls.
V) Coadministration of alphamethyldopa and cowpea
(60% and 20°/oW/w) had no effect on the b.p. of NTR,
but reduced that of SHR, Interaction of alphamethyldopa
with cowpea (20%w/w) increased the heart rate
of both NTR and SHR. Similarly, cowpea (60%w/w)
elevated the heart rate of SHR, but had no such
effect on NTR. The sympathomimetic effects followed
the pattern of responses obtained when administered to rats
(NTR and SHR) treated with only cowpea (20% and 60%w/w) .
The treatment apparently had no influence on the effects
of the sympathomimetics,
Description
A
THESIS
Submitted to
Ahmadu Bello University, Zaria. In
partial fulfillment for the degree of
Master of Science in Pharmacy.
Department of Pharmacology
Faculty of Pharmaceutical Sciences
November, 1980
Keywords
STUDIES,, INVOLVING,, INTERACTION,, ALPHAMETHYLDOPA,, COWPEA,, (VIGNA SINENSIS),, NORMOTENSIVE,, SPONTANEOUSLY,, HYPERTENSIVE,, RATS.