HEPATIC AND SERUM ENZYME CHANGES AFTER LINDANE POISONING IN RATS
HEPATIC AND SERUM ENZYME CHANGES AFTER LINDANE POISONING IN RATS
No Thumbnail Available
Date
1998-05
Authors
AKINLOYE, F. FATIMA
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Acute and Chronic toxicity studies of lindane were carried out on rat using biochemical
changes as indices of toxicity. The calculated LD50 was 25.4 mg per Kg body weight using
the arithmetic method of Karber. The symptoms of toxicity were observed and scored by
specific points according to the severity of symptoms of poisoning. Symptoms of toxicity
observed include tremor, prostration, pallor, convulsion and death of the animal.
Some serum biochemical parameters were analysed to evaluate the effect of lindane on
the liver. The parameters includes Aspartate aminotransferase (AST), Alanine
aminotransferase (ALT), Alkaline phosphatase (ALP), total protein (TP) and serum albumin
(SA). ALT showed the most significant alteration throughout the study period. ALT is
more sensitive to liver damage than AST. The other parameters showed no significant
alteration.
Histopathological examination of the liver indicates inflammation, congestion of the
liver and fatty degeneration after prolonged exposure. The symptoms of poisoning were
dose dependent in most cases
Description
A thesis submitted to the Postgraduate School,
Ahmadu Bello University, Zaria,
in partial fulfillment of the requirements for the
award of the Master degree in Pharmacology.
Department of Pharmacology and Clinical Pharmacy,
Faculty of Pharmaceutical Sciences,
Ahmadu Bello University,
Zaria, Nigeria.
MAY, 1998
Keywords
HEPATIC,, SERUM ENZYME,, LINDANE,, POISONING IN RATS