EFFECTS OF SEX, AGE, BODY MASS INDEXAND SEASONON SERUM THYROID HORMONES AND THYROID STIMULATING HORMONE IN RED SOKOTO AND SAHEL GOATS

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dc.contributor.authorBuhari, HABIBU,
dc.date.accessioned2016-01-20T08:47:43Z
dc.date.available2016-01-20T08:47:43Z
dc.date.issued2015-06
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSGRADUATE STUDIES AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT FOR THE AWARD OF A DECREE OF MASTERS OF SCIENCE IN VETERINARY PHYSIOLOGY DEPARTMENT OF PHYSIOLOGY AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractThyroid hormones are the most important hormones involved in the regulation of cellular metabolism, reproductive seasonality, voluntary feed intake and thermogenic adaptation to changes in ambient temperature in mammals and birds. This study was aimed at evaluating the influence of sex, age, body mass index (BMI) and season on serum thyroxin (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH) and T3:T4 of Red Sokoto (RSG) and Sahel (SHG) goat kids. A total of 240 blood samples were collected from apparently healthy goat kids at the peak of each of the three seasons of the year, that is the cold-dry (CDS), hot-dry (HDS) and rainy (RAS) seasons. In each season, 80 goats were sampled as follows: RS buck-kids (n=10), RS bucks (n=10), RS doe-kids (n=10), RS does (n=10), SH buck-kids (n=10), SH bucks (n=10), SH doe-kids (n=10) and SH does (n=10). The T3:T4 was calculated and used as an indirect measure of the conversion of T4 to T3. The HDS had significantly higher (P < 0.05) temperature-humidity index (84.62) than the RAS (79.63) and CDS (74.45). The results of this study revealed that the overall mean values of circulating concentrations of T3, T4 and TSH in these breeds of goats were 2.14 ± 0.087 ng/mL, 45.90 ± 1.90 ng/mL and 0.80 ± 0.036 μIU/mL. Irrespective of season, sex and age, mean serum concentrations of T3 and T4 were significantly higher (P < 0.05) in RS than SH goats. The RS kids had higher (P < 0.05) T3:T4 than SH goat kids during the RAS. In RS, female goats had higher (P < 0.05) serum T3 and T4 than males in the RAS. Similarly, female SH goats had higher (P < 0.05) T3 and T4 than males in the CDS and RAS, respectively. In the RS, serum TSH (HDS) and T3:T4 (CDS) were significantly higher in males than female goats. In SH goats, however, females had higher (P < 0.05) T3:T4 than males. In both breeds, kids had significantly higher (P < 0.05) serum T3 and T4 than adult goats. In contrast, adult RS goats had significantly higher (P < 0.05) serum TSH than goat kids. The T3:T4 was significantly higher (P < 0.05) in RS kids than adult goat during the HDS. Irrespective of age and breed,serum T3 levels were significantly lower (P <0.05) during the HDS compared to CDS and RAS. The SH goats had lower (P < 0.05) serum TSH during the HDS compared to RAS. In both RS and SH kids, mean T3:T4 value was significantly lower (P < 0.05) during the HDS compared to CDS and RAS. There was a significantly negative correlation (r = -0.776; P < 0.05) between T3 and BMI in kids of SH goats during the HDS. A positive correlation (r = 0.619; P < 0.05) was recorded between TSH and BMI in SH goat kids (HDS), while the correlation was negative (r = - 0.575; P < 0.05) in the RS goat kids (RAS). The correlation between T3:T4 and BMI was positive (r = 0.900; P < 0.05) in female kids of RS goats in CDS. However, it was negative (r = 0.749; P < 0.05) in SH goats kids during the HDS. In adult RS goats, the correlation between T3 and BMI was positive (r = 0.611; P < 0.05) in the CDS; positive (r = 0.620; P < 0.05) for T4 and BMI in CDS; and negative (r = 0.545; P < 0.05) for T4 and BMI in HDS. In adult SH goats, the correlation between T4 and BMI was negative (r = -0.795; P < 0.05) in male goats during the RAS and negative (r = - 0.862; P < 0.05) between TSH and BMI in females goats during the HDS. It is concluded that breed, sex, age, BMI and season affects serum concentrations of thyroid hormones and TSH in RS and SH goats reared in Zaria in the Northern Guinea Savannah zone of Nigeria.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7311
dc.language.isoenen_US
dc.subjectEFFECTS,en_US
dc.subjectSEX,en_US
dc.subjectAGE,en_US
dc.subjectBODY,en_US
dc.subjectMASS,en_US
dc.subjectINDEX,en_US
dc.subjectSEASONON,en_US
dc.subjectSERUM,en_US
dc.subjectTHYROID,en_US
dc.subjectHORMONES,en_US
dc.subjectTHYROID,en_US
dc.subjectSTIMULATING,en_US
dc.subjectHORMONE,en_US
dc.subjectRED,en_US
dc.subjectSOKOTOen_US
dc.subjectSAHEL GOATSen_US
dc.titleEFFECTS OF SEX, AGE, BODY MASS INDEXAND SEASONON SERUM THYROID HORMONES AND THYROID STIMULATING HORMONE IN RED SOKOTO AND SAHEL GOATSen_US
dc.typeThesisen_US
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