IMMUNITY ENGENDERED THROUGH SELF-CURE IN ZEBU CALVES EXPERIMENTALLY INFECTED WITH TRYPANOSOMA VIVAX
IMMUNITY ENGENDERED THROUGH SELF-CURE IN ZEBU CALVES EXPERIMENTALLY INFECTED WITH TRYPANOSOMA VIVAX
No Thumbnail Available
Date
1984-01
Authors
NDUBISI, RAPHAEL UZOIGWE
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The response of White Fulani Zebu calves to primary
Trypanosoma vivax infection was observed over a period of 24
weeks. This was followed by a study of the effects of challenge
infection with a homologous strain on the calves. The calves
were between the ages of six and 12 months and were purchased
from Jibiya, a tsetse-free area of Nigeria. A stock of
T. vivax isolated from Ilorin in Kwara State of Nigeria was
used for the primary inoculation and later for the homologous
challenge. Each of the eight calves used as the experimental
group was inoculated through the jugular vein with 1.6 x 108
trypanosomes. Three other calves served as the control.
Temperature, parasitemia, PCV, Hb concentration, leukocyte
changes and weight gain/loss were monitored. All the eight
calves became infected after prepatent periods ranging
between two and five days. Three (38%) out of the eight
infected calves died. All calves that survived after the
third week of infection were self-cured. High parasitemia
and anemia were observed in the dead calves. The surviving
calves showed early signs of recovery from the anaemia and exhibited
ability to control the parasitemia. None of the four self-cured
calves became infected following challenge with the homologous
strain while the three control calves became infected.
In both the primary and challenge infections the white
blood cell picture did not seem to indicate adverse effect
on the lymphoid system of the infected calves. It is concluded
from this study that immunization of calves with live
trypanosomes may have potentials for the control of
trypanosomiasis in the field.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL
AHMADU BELLO UNIVERSITY, IN PARTIAL FULFILLMENT
OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF
SCIENCE (M.Sc)
DEPARTMENT OF VETERINARY PARASITOLOGY AND ENTOMOLOGY
FACULTY OF VETERINARY MEDICINE
JANUARY, 1984
Keywords
IMMUNITY,, ENGENDERED,, SELF-CURE,, ZEBU CALVES,, EXPERIMENTALLY INFECTED,, TRYPANOSOMA VIVAX