INFLUENCE OF SOME GABAergic AGENTS ON DRUG-INDUCED BEHAVIOUR IN CHICKS AND RATS
INFLUENCE OF SOME GABAergic AGENTS ON DRUG-INDUCED BEHAVIOUR IN CHICKS AND RATS
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Date
1984-01
Authors
SALAWU, OLUWAKANYINSOLA ADEOLA
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Abstract
The influence of some GABAergic agents on
drug-induced stereotyped behaviour as a model of DA
activation was studied in conscious young chicks.
Apomorphine and d-amphetamine produced
dose-dependent stereotyped behaviour and
d-amphetamine was observed to be less potent in
producing this effect and in addition produced
postural changes in the chicks.
Gama-aminobutyric acid (GABA), aminooxyacetic
acid (AOAA), gama-hydroxybutyrate (GHB)
4,5,6 7-tetrahydroisoxazolo 5,4-c-pyridin-
3-ol (THIP) produced behavioural depression and
sedation in chicks especially at lower doses
while the GABA antagonist, bicuculine produced
behavioural excitation,
Pretreatment of chicks with GABA, THIP, AOAA
and GHB antagonized apomorphine and d-amphetamineinduced
stereotyped behaviour while bicuculine
potentiated the stereotypies induced by both drugs
and also antagonized the effects of GABA, THIP and
AOAA on apomorphine-induced stereotyped behaviour.
EEG studies using the GABAergic drugs on
their own and in combination with the DA agonists
substantiated the behavioural observations above.
Effect of some catecholaminergic agents on
influence of GABAergic drugs on apomorphine and
d-amphetamine-induced stereotyped behaviour were
studied in chicks.
Description
A thesis submitted to the Postgraduate School,
Ahmadu Bello University, in partial fulfilment
of the requirements for the degree of:
Master of Science
Department of Pharmacology &
Clinical Pharmacy
Faculty of Pharmaceutical Sciences,
Ahmadu Bello University,
Zaria.
January 1984.
Keywords
INFLUENCE,, GABAergic,, DRUG-INDUCED,, CHICKS AND RATS