ANTICONVULSANT SCREENING OF CHLOROFORM-SOLUBLE FRACTION OF METHANOLIC STEM-BARK EXTRACT OF LONCHOCARPUSSERICEUS, POIR (PAPILIONACEAE)
ANTICONVULSANT SCREENING OF CHLOROFORM-SOLUBLE FRACTION OF METHANOLIC STEM-BARK EXTRACT OF LONCHOCARPUSSERICEUS, POIR (PAPILIONACEAE)
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Date
2012-09-29
Authors
Abdullahi, S.M
Musa, A.M
Yaro, A.H
Magaji, M.G
Sule, M.I.
Sani, Y.M.
Journal Title
Journal ISSN
Volume Title
Publisher
Biological and Environmental Sciences Journal for the Tropics
Abstract
Lonchocarpus sericeus is used in African traditional medicine in the management of epilepsy.
Previous study showed that the crude methanol extract possess significant anticonvulsant activity.
In this study, the chloroform soluble portion of the methanol extract of the stem bark of
Lonchocarpus sericeus was screened for anticonvulsant activity using maximal electroshock test in
chicks, 4-aminopyridine andpentylenetetrazols induced seizures in mice. The fraction (ISO mgkg1)
protected 50% of the animals against pentylenetetrazole induced seizure in mice whereas sodium
valproate, a standard anti-epileptic drug, offered 100% protection. In 4-aminopyridine induced
seizure model, the fraction at doses of 75 and 300 mgkg'1 protected 33.3% of the animals against
mortality, but phenobarbitone (20mgkg1) protected 100%. There was no activity against maximal
electroshock convulsion. Phytochemical screening of the fraction revealed the presence of phenolic
compounds, flavonoids, triterpenoids and steroids. The fraction was found to have an
intraperitoneal LDS0 of 1131.3 mgkg'1. The results showed that the fraction contains compounds
with some anticonvulsant activity worthy of further investigations.
Description
1Department of Pharmaceutical and Medicinal Chemistry, 3Department of Pharmacology and Therapeutics,
Ahmadu Bello University, PMB 1045, Zaria, Nigeria
2Department of Pharmacology, Bayero University, PMB 3011, Kano, Nigeria
(*Correspondence: smabdullahi@abu.edu.nq; +234-803-6162484)
Keywords
ANTICONVULSANT,, CHLOROFORM-SOLUBLE,, FRACTION,, METHANOLIC,, STEM-BARK EXTRACT,, LONCHOCARPUSSERICEUS,, POIR (PAPILIONACEAE)