The Effect of Temperature Fluctuation In The Tropics On The Viscoelastic Properties of Clotrimazole (an antifungal) Cream Bases
The Effect of Temperature Fluctuation In The Tropics On The Viscoelastic Properties of Clotrimazole (an antifungal) Cream Bases
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Date
1983-03
Authors
ABUBAKAR, MUSA
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Abstract
The physicochemical factors affecting semi-solids
and in particular emulsified creams have been reviewed.
Temperature, humidity, pH changes, Oxidation-rednction
processes and microbial contamination are such factors
that generally affect the stability of Pharmaceutical
and Cosmetic creams.
The flow properties and types of flow of various
types of pharmaceutical fluids and semi-solids have
also been outlined.
An investigation on the macroscopical and
rheological properties such as apparent plastic
viscosity, yield stress and thixotropy using
Ferrenti-Shirley cone and plate viscometry was
carried out on various cream bases at different
temperatures. Cetostearyl alcohol/Cetyltrimethyl
Ommonium oromide were used as mixed emulsifier.
The effects of alcohol/surfactant ratio and the
total mixed emulsifier concentrations on the viscoelastic
properties have also been investigated,
The results of these investigations indicated
that temperature fluctuations common to tropical
climates affect the physical stability of the creams
drastically. It was found that the consistency
usually increases with rise in temperature to a
maximum of around 20° - 27° and decreases with
further increase therefrom. An exact temperature
of maximum stability of 20° was also found to be the
same for the commercial sample "Canesten Cream" in
the comparative studies conducted in this work,
Description
A Thesis submitted to the post graduate school
In Partial Fulfillment for the Degree of
Master of Science (Pharmacy) of the
Ahmadu Bello University, Zaria
Department of Pharmaceutics & Pharmaceutical Microbiology
Faculty of Pharmaceutical Sciences
Ahmadu Bello University, Zaria
March, 1983
Keywords
EFFECT,, TEMPERATURE,, FLUNCTUATIONS,, CLOTRIMAZOLE,, Tropics,, Viscoelastic,, Properties,, Clotrimazole,, (an antifungal), Cream,, Bases.