THE INFLUENCE OF METRONIDAZOLE ON THE PHARMACOKINETIC PROFILE OF CHLORPROPAMIDE IN TYPE II DIABETIC PATIENTS
THE INFLUENCE OF METRONIDAZOLE ON THE PHARMACOKINETIC PROFILE OF CHLORPROPAMIDE IN TYPE II DIABETIC PATIENTS
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Date
1998-09
Authors
BELLO, KUDIRAT
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Abstract
The influence of metronidazole on the pharmacokinetic profile of chlorpropamide in Type
II diabetic patients was examined. The quality of chlorpropamide and metronidazole tablets
used in the study were pre -determined using official methods. The tablets complied with
the BP (1988) requirements stated under the monograph for chlorpropamide and
metronidazole tablets.
Plasma levels of chlorpropamide were determined using colorimctric method (Martin et
al, 1973). In addition, glucose levels were measured by standard glucose oxidase method
(Martinek, 1964). Decreased levels of chlorpropamide were observed in concomitant
administration of 250mg chlorpropamide with two 200mg metronidazole tablets(C)
compared with administration of 250mg chlorpropamide tablet (control) (B). Insignificantly
higher (pre and postprandial) levels of plasma glucose were observed in concomitant
administration of metronidazole with chlorpropamide compared with administration of
250mg chlorpropamide alone.
The pharmacokinetic parameters were calculated using semi - logarimathmic plots of concentration- time data for chlorpropamide. The area under the curve was calculated by
trapezoidal rule. Administration of metronidazole concomitantly with chlorpropamide
significantly affected some pharmacokinetic parameters of chlorpropamide such as ka,
Cmax, Vd, AUG, and ti/2Ct. The elimination parameters, Lag time, and tmax as calculated
in this study were not significantly affected.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT
OF THE REQUIREMENTS FOR THE AWARD OF MASTER DEGREE
DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY,
FACULTY OF PHARMACEUTICAL SCIENCES,
AHMADU BELLO UNIVERSITY, ZARIA
Keywords
INFLUENCE,, METRONIDAZOLE,, PHARMACOKINETIC,, PROFILE,, CHLORPROPAMIDE,, TYPE II,, DIABETIC,, PATIENTS.