VITAMIN E AND SELENIUM STATUS IN HEALTH AND DISEASE
VITAMIN E AND SELENIUM STATUS IN HEALTH AND DISEASE
No Thumbnail Available
Date
1981-05
Authors
ELELU, MASHUD AKANBI
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Vitamin E and selenium status of 45 healthy and 90
unhealthy human subjects were assessed. Vitamin E status was
assessed as erythrocyte hemolysis (%) while selenium as erythrocyte
glutathione peroxidase activity. The mean values
for healthy control subjects were 5.4± 0.59 for erythrocyte
hemolysis (%) and 3.8 x 10-± 0.34 units for glutathione
peroxidase activity. There was no significant difference
(P> 0.05) between these values and those for the unhealthy
ones studied except for subjects with heart muscle diseases.
Erythrocyte hemolysis (%) and erythrocyte activity were significantly
lower (p<0.05) in subjects with heart muscle diseases
compared to the controls. Erythrocyte glutathione and
plasma ascorbic acid were also assessed in the subjects. In
the control glutathione level was 38.± 4.03 mg per 100 ml
and plasma ascorbic acid was 0.70 ± 0.14 mg per 100 ml. The
values were not affected significantly by vitamin E and selenium
status of the subjects as also by diseased status
studied. A vitamin E deficient male subject had a mean of
18.5 and 2.76 x 10-2 units as erythrocyte hemolysis (%) and
glutathione peroxidase activity respectively over a period
of 5 weeks. These values dropped significantly (P< 0.05)
when the subject was given oral 60 mg d x-tocopherol per day
for 3 days. This indicated a metabolic interrelationship of
vitamin E with selenoenzyme glutathione peroxidase. This
observation needs further investigations. As reported in
earlier works, glutathione peroxidase activity in the rats
studied, was located more with the cytosal than the mitochondria.
Complete starvation for 48 hours in the rats increased
the activity of the selenoenzyme significantly by 62.5% in
the cytosol without any effect on it's mitochondrial activity.
Description
A Thesis Submitted in Partial
Fulfillment of the Requirments
for the Degree of:
MASTER OF SCIENCE
Keywords
VITAMIN E, SELENIUM, STATUS, HEALTH, DISEASE