ASSESSMENT OF SERUM CYSTATIN C, CREATININE AND ESTIMATED GLOMERULAR FILTRATION RATE IN PATIENTS WITH CHRONIC KIDNEY DISEASE IN ZARIA, NIGERIA

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dc.contributor.authorADAMU, Rabiu
dc.date.accessioned2016-06-28T09:21:50Z
dc.date.available2016-06-28T09:21:50Z
dc.date.issued2015-05
dc.descriptionA DISSERTATIONSUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF A MASTER DEGREE IN CHEMICAL PATHOLOGY DEPARTMENT OF CHEMICAL PATHOLOGY FACULTY OF MEDICINE AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractThe limitations of serum creatinine as a marker of impairment in GFR have led to continuing search for a better marker. Most studies have shown that serum cystatin C may be a more sensitive indicator of glomerular filtration rate (GFR) than serum creatinine in the clinical setting. This study was designed to evaluate serum cystatin C,creatinineand estimated GFR (eGFR)in Chronic Kidney Disease (CKD) patients. One hundred and fourteen (114) CKD Patients (comprising 59 males and 55 females) attending Nephrology Clinic at ABUTH and apparently healthy age and sex matched controls were recruited for the study. Serum creatinine and cystatin C were assayed by the Jaffe kinetic and immunoturbidimetric methods respectively. Estimated GFR was calculated usingthe Cockcroft-Gault (C-G) formula. Serum creatinine, cystatin C and Estimated GFR (eGFR) in patients and controls were comparedusing the t-test. Relationships between serum cystatin C, creatinine and estimated GFR were analysed using the Pearson’s correlation. In this study,serumcystatin C and creatinine were significantly higher(p<0.0001)and estimated GFR significantly lower (p<0.0001) in patients than the control subjects.Cystatin C was better correlated with Estimated GFR (r =-0.708;p<0.0001) than creatinine (r =-0.694;p<0.0001). Mean cystatin C concentration showed step-by-step statistically significant increase as GFR decreases, allowing very early detection of reduction in renal function. The findings from this study showed that serum cystatin C is a better marker compared with serum creatininein evaluating GFR particularly for detecting very early reduction of renal function. Use of cystatin C to assess renal function will optimize early detection,treatment and monitoring strategies forpatients with CKD.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8016
dc.language.isoenen_US
dc.subjectASSESSMENT,en_US
dc.subjectSERUM CYSTATIN C,en_US
dc.subjectCREATININE,en_US
dc.subjectESTIMATED GLOMERULAR FILTRATION RATE,en_US
dc.subjectPATIENTS,en_US
dc.subjectCHRONIC KIDNEY DISEASE,en_US
dc.subjectZARIA,en_US
dc.subjectNIGERIAen_US
dc.titleASSESSMENT OF SERUM CYSTATIN C, CREATININE AND ESTIMATED GLOMERULAR FILTRATION RATE IN PATIENTS WITH CHRONIC KIDNEY DISEASE IN ZARIA, NIGERIAen_US
dc.typeThesisen_US
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