THE EFFECTS OF TEMPERATURE AND TYPE OF MOUSE BEDDING ON THE INFECTIVITY OF HUMAN SCHISTOSOME TYPE CERCARIAE IN MICE

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dc.contributor.authorONYABE, DAVID YETU
dc.date.accessioned2014-02-14T12:06:25Z
dc.date.available2014-02-14T12:06:25Z
dc.date.issued1993-04
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE (M.Sc) IN ZOOLOGYen_US
dc.description.abstractFive batches of mice each batch consisting of five replicates were exposed to cercariae at the rate of 200 cercariae per mouse at 5°C, 15OC, 25°c, 35°C and 45°C. It was observed that cercariae maintained at 25°C had the highest infectivity (15.2%) and those maintained at 45°C the lowest (1.8%). Infectivity of cercariae at 5°C was zero. Except for mice exposed to cercariae at 5°C, the Hb, g/lOOml and PCV%, of mice infected at other temperatures differed significantly (P<0.05) from those of the uninfected control. The tissue and faecal egg count, and wormload of mice infected at 15, 35 and 45°c also differed significantly (P<0.05) from those of mice infected at 25°C. In another experiment, freshly emerged cercariae were stored at constant temperature (5°C) for 3,6,12 and 24 hour periods after which they were slowly warmed to 25 ± 1°C and used to infect four batches of mice, the batches corresponding with the four periods of storage. A fifth batch of mice was infected with freshly emerged cercariae and served as the infected control while a sixth batch served as an uninfected control. The results showed an inverse relationship between infectivity of cercariae and duration of storage. The wormload, tissue and faecal egg counts of infected mice differed significantly (P<0.05) from those of the infected control regardless of duration of storage of cercariae while the Hb, g/lOOml and PCV% of infected mice except those exposed to cercariae cold stored for 24 hours differed significantly (P<0.05) from those of the uninfected control. In yet another experiment one batch of five mice was reared on sawdust bedding and another batch of five mice was reared on shredded paper bedding for 7 days. It was found that infectivity of cercariae to mice maintained on shredded paper was higher than to mice on sawdust bedding. For all the indices of infectivity investigated, there was a significant difference (P<0.05) between shredded paper bred and sawdust bred mice.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1573
dc.language.isoenen_US
dc.subjectEFFECTS,en_US
dc.subjectTEMPERATURE,en_US
dc.subjectTYPE,en_US
dc.subjectMOUSE BEDDING,en_US
dc.subjectINFECTIVITY,en_US
dc.subjectHUMAN,en_US
dc.subjectSCHISTOSOME,en_US
dc.subjectTYPE,en_US
dc.subjectCERCARIAE,en_US
dc.subjectMICEen_US
dc.titleTHE EFFECTS OF TEMPERATURE AND TYPE OF MOUSE BEDDING ON THE INFECTIVITY OF HUMAN SCHISTOSOME TYPE CERCARIAE IN MICEen_US
dc.typeThesisen_US
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